Dominick P. Purpura Department of Neuroscience

Past Club Syn Journal Clubs



12/11/15 Jose Luis Peña
Griffin DM, Hoffman DS and Strick PL. Corticomotoneuronal cells are "functionally tuned". Science. 350(6261): pp. 667-70, 2015. 
11/13/15 Michael Bennett
Li M et al. Physical basis of apparent pore dilation of ATP-activated P2X receptor channels. Nat Neurosci. 18: pp. 1577-83, 2015. 
9/11/15 Ariel Vitenzon
von Reyn CR et al. A spike-timing mechanism for action selection. Nat Neurosci. 17(7): pp. 962-70, 2014. 
3/23/15 Pablo Lituma
Temprana SG et al. Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells. Neuron. 85(1): pp. 116-30, 2015. 
1/23/15 Randy Stout
Flašker A et al. Vesicle size determines unitary exocytic properties and their sensitivity to sphingosine. Mol Cell Endocrinol. 376(1-2): pp. 136-47, 2013. 
1/16/15 Christopher Chen
Llinás R and Sugimori M. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol. 305: pp. 171-95, 1980. 



12/19/14 Ilaria Carta
Vélez-Fort M et al. The stimulus selectivity and connectivity of layer six principal cells reveals cortical microcircuits underlying visual processing. Neuron. 83(6): pp. 1431-43, 2014. 
11/7/14 Thomas Younts
Trenholm et al. Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations. Nat Neurosci, 17(12): pp. 1759-66, 2014. 
10/24/14 Alberto Pereda
Watanabe et al. Clathrin regenerates synaptic vesicles from endosomes. Nature, 515(7526): pp. 228-33, 2014. 
10/3/14 Stefano Lutzu
Root et al. Single rodent mesohabenular axons release glutamate and GABA. Nat Neurosci, 17(11): pp. 1543-51, 2014. 
9/15/14 Bryen Jordan
Pecho-Vrieseling et al. Transneuronal propagation of mutant huntingtin contributes to non-cell automomous pathology in neurons. Nat Neurosci, 17(8): pp. 1064-72, 2014. 
5/2/14 Randy Stout
Pannache et al. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat Neurosci 17, pp. 549-58, 2014. 
4/25/14 Steven Cook
Chia PH, et al. Local F-actin network links synapse formation and axon branching. Cell 156, pp. 208-20, 2014. 
3/21/14 Kyle Jensen
Soto F, et al.  NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina. J Neurosci 33, pp. 11949-59, 2013. 
3/7/14 Yonatan Fishman

Gil-da-Costa, R, et al. Nonhuman primate model of schizophrenia using a noninvasive EEG method. Proc Natl Acad Sci USA 110, pp. 15425-30, 2013. 

2/21/14 Stephen Briggs

Clasadonte J, et al. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy. Proc Natl Acad Sci USA 110, pp. 17540-45, 2013 

1/31/14 Pablo Castillo
Bemben et al. "CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses".  Nature Neuroscience 17, pp. 56–64, 2014.  
1/17/14 Christopher Chen
Lee et al. "Hippocampal Place Fields Emerge upon Single-Cell Manipulation of Excitability During Behavior." Science 337, pp. 849-53, 2012. 



12/13/13 Magdalena Kalinowska
Baudouin et al. "Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism". Science 338, pp. 128-132, 2012. 
12/06/13 Scott Emmons
Helmstaedter et al. "Connectomic reconstruction of the inner plexiform layer in the mouse retina". Nature 500:168-174, 2013. 
11/22/13 Donald Faber
Smith et al.  "Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo". Nature 503, pp. 115-120, 2013. 
11/01/13 Alexander Pyronneau
Huang et al. "mTORC2 Controls Actin Polymerization Required for Consolidation of Long-Term Memory"
Nature Neuroscience 16, pp. 442-448, 2013.
10/18/13 Scott Nawy
Puthussery et al. "NaV1.1 Channels in Axon Initial Segments of Bipolar Cells Augment Input to Magnocellular Visual Pathways in the Primate Retina".  J. Neuroscience 33, pp. 16045-16059, 2013.  
10/4/13 Yuki Hashimotodani
 Dölen et al. "Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin." Nature 501, pp. 179-84, 2013. 
9/27/13 Dana Savariego
Shao et al. "Synapse Location during Growth Depends on Glia Location." Cell 154, pp. 337-50, 2013. 
9/6/13 Sofia Jürgensen
 Li et al. "βCaMKII in lateral habenula mediates core symptoms of depression." Science 341, pp. 1016-20, 2013. 
6/21/13 Carolina Soto
 Aoki et al. "Imaging of Neural Ensemble for the Retrieval
of a Learned Behavioral Program." Neuron 78, pp. 881-94, 2013.
5/31/13 Adam Kohn
Herrero et al. "Attention-Induced Variance and Noise Correlation Reduction in Macaque V1 Is Mediated by NMDA Receptors." Neuron 78, pp. 729-39, 2013. 
5/10/13 Randy Stout
Carta et al. "CaMKII-dependent phosphorylation of GluK5
mediates plasticity of kainate receptors." EMBO J 32, pp. 496-510, 2013.
4/19/13 Shlomo Dellal
Cai et al. "Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression." Nat Neurosci 16, pp. 464-72, 2013. 
4/5/13 Kirsty Sawicka
Clement et al. "Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses." Cell 151, pp. 709-23, 2012. 
3/22/13 Michael Gertner
Peixoto et al. "Transsynaptic signaling by activity-dependent cleavage of neuroligin-1." Neuron 76, pp. 396-409, 2012. 
3/8/13 Jaafar Tindi
Karpova et al. "Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus." Cell 152, pp. 1119-33, 2013. 
2/15/13 Matt Klein
Santini et al. "Exaggerated translation causes synaptic and behavioral aberrations associated with autism." Nature 493, pp. 411-5, 2013. 
1/25/13 Andres Chavez
Granger et al. "LTP requires a reserve pool of glutamate receptors independent of subunit type." Nature 493, pp. 495-500, 2013.
1/11/13 Karina Alvina
Volk et al. "PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory." Nature 493, pp. 420-3, 2013. 



12/7/12 Helmuth Sanchez
Graves et al. "Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors." Neuron 76, pp. 776-89, 2012. 
11/16/12 Yunyan Wang
Washington & Kanwal. "Sex-dependent hemispheric asymmetries for processing frequency-modulated sounds in the primary auditory cortex of the mustached bat.", J Neurophysiol 108, pp. 1548-66, 2012. 
11/2/12 Jose Luis Pena
Ahrens et al. "Brain-wide neuronal dynamics during motor adaptation in zebrafish." Nature 485, pp. 471-9, 2012. 
10/26/12 Eliana Scemes
Choi et al. "Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase." Neuron 75, pp. 1094-1104, 2012. 
9/28/12 Scott Nawy
Schiemann et al. "K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration." Nat Neurosci 15, 1272-80, 2012. 
9/14/12 Eduardo Arteaga-Bracho
Oliveira et al. "Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities." Nature Neurosci 15, pp. 1111-3; 2012. 
8/31/12 Reed Carroll
Polosukhina et al. "Photochemical restoration of visual responses in blind mice." Neuron 75, pp. 271-82, 2012. 
8/17/12 Tommy Younts
Vervaeke et al. "Gap junctions compensate for sublinear dendritic integration in an inhibitory network." Science 335, pp. 1624-8, 2012. 
2/24/12 Bryen Jordan
Darnell et al. "FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism." Cell 146, pp. 247-61, 2011. 
2/17/12 Magdalena Kalinowska
Cui-Wang et al. "Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites." Cell 148, pp. 309-21, 2012. 
1/27/12 Ariel Vitenzon
Di Castro et al. "Local Ca2+ detection and modulation of synaptic release by astrocytes." Nat Neurosci 14, pp. 1276-84, 2011. 



12/16/11 Diana Pettit
Bartal et al. "Empathy and pro-social behavior in rats." Science 334, pp. 1427-30, 2011. 
12/9/11 Saleem Nicola
Conrad et al. "Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving." Nature 454, pp. 118-21, 2008. 
12/2/11 Jack-Christophe Cossec
Lippi et al. "Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology." J Chem Biol 194, pp. 889-904, 2011. 
11/18/11 Zaven Kaprielian
Williams et al. "Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus." Neuron 71, pp. 640-55, 2011. 
10/7/11 Michael Gertner
Restituito et al. "Synaptic autoregulation by metalloproteases and y-secretase." J Neurosci 31, pp. 12083-93, 2011.  
9/22/11 Tanya Casimiro
AMPAR Cycling and Activity Dependent Regulation of Synaptic Function 
5/27/11 David Hunt
Jia et al. "Dendritic organization of sensory input to cortical neurons in vivo." Nature 464, pp. 1307-12, 2010. 
4/29/11 Naama Rotem
Harvey et al. "Intracellular dynamics of hippocampal place cells during virtual navigation." Nature 461, pp. 941-6, 2009. 
4/22/11 Scott Emmons
Seung. "Neuroscience: Towards functional connectomics." Nature 471, pp. 170-2, 2011 
3/25/11 Diana Pettit
Larsen et al. "NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity." Nat Neurosci 14, pp. 338-44, 2011. 
3/3/11 Michael Bennett
Rauner & Kohr. "Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses." J Biol. Chem 286, pp. 7558-66, 2011. 
1/28/11 Pablo Castillo
Govindarajan et al. "The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP." Neuron 69, pp. 132-46, 2011. 
1/14/11 Sachin Makani
Christie et al. "Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization." Nat Neurosci 14, pp. 62-8, 2011. 

Recent News & Events

Publication | Dr. Kamran Khodakhah
New Target For Dystonia Therapy—Dystonia—when someone’s muscles contract uncontrollably—is the third most common movement disorder (after Parkinson’s and essential tremor), affecting about 250,000 Americans. Research and treatment for the most common inherited form of dystonia, called DYT1, has focused mainly on the basal ganglia region of the brain. But new animal research by Einstein scientists implicates a different part of the brainthe cerebellumas the site of the problem. The study, published in the February 15 online issue of eLife, was led by Kamran Khodakhah, Ph.D., professor and chair of the Dominick P. Purpura Department of Neuroscience and the Harold and Muriel Block Chair in Neuroscience. He and his colleagues made their discovery after generating the first mouse model of DYT1 to exhibit the overt symptoms of dystonia seen in patients. Previous research in Dr. Khodakhah’s lab has shown that severing the link between the cerebellum and the basal ganglia might be an effective way to treat cerebellar-induced dystonias....more

Event | Neuroscience Retreat - May 10th - 11th
The Neuroscience Retreat will be held from May 10th - May 11th, 2017 at the Edith Macy Conference Center. Additional information, including itinerary and poster signups has been posted here. Registrations are due April 19th....more

more news and events


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