The Saul R. Korey Department of Neurology

Cognitive Trajectories of the PASAT and SDMT and their relations to clinical and functional outcomes in Multiple Sclerosis

10/10 – 10/11
Type: Investigator-Initiated
Principal Investigator: R. Holtzer
Agency: Bayer


The Paced Auditory Serial Addition Test (PASAT) and Symbol Digit Modalities Test (SDMT) are commonly used to assess cognitive status and decline in patients with Multiple Sclerosis (MS). However, whether these tests can serve as primary outcomes in MS clinical trials has not been determined. This proposal is designed to achieve the following specific aims: 1. To identify separate cognitive trajectories on the PASAT and SDMT within one session and over two additional monthly follow-up assessments. 2. To examine whether separate cognitive trajectories on the PASAT and SDMT are related to disease status and functional outcomes in MS.

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Verghese Gait Video Geriatrician Joe Verghese explains how subtle changes in gait can identify which patients are at risk for frailty – with the goal of preventing falls and mental decline. Dr. Verghese is chief of geriatrics at Einstein and Montefiore Medical Center and a professor of neurology and of medicine at Einstein. This edition of Einstein On, a research and medicine podcast, is hosted by Paul Moniz, managing director of communications and marketing at Albert Einstein College of Medicine.

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