The Saul R. Korey Department of Neurology

CREM - Cognitive Remediation Study

LENGTH OF STUDY 08/15–04/20
Type: R01 6R01AG050448-02
Principal Investigator: J. Verghese and R. Holtzer
Agency: National Institute on Aging

We propose to conduct the first single-blind randomized clinical trial to test the efficacy of cognitive remediation to improve mobility in seniors.  Our hypothesis is that mobility and executive function are linked via frontal cortices, basal ganglia, and their connections; and neuroplasticity can occur in these areas in response to computerized cognitive remediation (C-REM).  The Short Physical Performance Battery (SPPB) includes tests of balance, gait speed, and chair rise, and along with gait speed is recommended as a primary mobility outcome measure for clinical trials.  Our primary outcomes are SPPB and gait speed during Normal Pace Walking and Walking While Talking conditions.  Gait variables other than speed (e.g., stride length variability) increase risk of disability and falls.  Yet, impairments in these gait variables may not respond to conventional interventions such as exercise.  Hence, we will also examine C-REM effects on an expanded gait and mobility battery as secondary outcomes.  We propose to randomize 420 seniors into either an 8-week C-REM or health education program to test our predictions.

Letter from the Chief 

New Developments

Verghese Gait Video Geriatrician Joe Verghese explains how subtle changes in gait can identify which patients are at risk for frailty – with the goal of preventing falls and mental decline. Dr. Verghese is chief of geriatrics at Einstein and Montefiore Medical Center and a professor of neurology and of medicine at Einstein. This edition of Einstein On, a research and medicine podcast, is hosted by Paul Moniz, managing director of communications and marketing at Albert Einstein College of Medicine.

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