Department of Molecular Pharmacology

Molecular Approaches to Drug Action and Design

COURSE LEADER: Dr. Matthew Gamble

CREDITS/CLASS MEETINGS: 3 semester hours; approximately 28 lectures.

PREREQUISITE BACKGROUND: Should have the equivalent of graduate school biochemistry.

SUITABILITY FOR 1ST YEAR STUDENTS: This course is not intended for first-year students. Consult with the course leader if there are any questions.

COURSE DESCRIPTION: This course will involve a discussion of drugs employed in the treatment of bacterial, viral, fungal, and parasitic disease, cardiovascular and CNS pathology, diabetes, and cancer. The principles of pharmacokinetics, pharmacodynamics, and drug metabolism, and the design of enzyme inhibitors as drugs will be studied. The molecular mechanisms of drug resistance will be analyzed. Emphasis will be placed on the biology and chemistry of interactions between chemotherapeutic agents and their cellular targets, including the bacterial cell wall, cell membrane components, transport processes, DNA, the ribosome, the cytoskeleton, and specific enzymes and receptors.

CREDIT HOURS: 3.0

LEVELS: Sue Golding Graduate Division

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