Areas of Research: Research focuses on small molecules of natural product origin, such as TaxolÂ®, which interact with the microtubule cytoskeleton. The goal is to understand, at a molecular level, the effects of drugs on tumor growth.
Areas of Research: Exploring how protein, DNA, and RNA structure, folding, and assembly determines the biological function of these macromolecules.
Areas of Research: Mechanisms of manganese-induced neurotoxicity, genetic factors associated with manganese toxicity, the role of dopamine signaling in susceptibility of dopaminergic neurodegeneration, metals in restless legs syndrome.
Areas of Research: Neuropeptides and other peptides that function in intercellular and intracellular signaling; peptidases that generate biologically active peptides.
Areas of Research: Histone variant macroH2A; Cancer; Cellular senescence; Chromatin structure and function; Transcription; Splicing; Senescence-associated secretory phenotype; Endoplasmic reticulum stress responses; Poly(ADP-ribose) polymerase
Areas of Research: Membrane transport of folates/antifolates; structure-function and regulation of the proton-coupled folate transporter; homology modeling; role in the activities of antifolates within the acidic microenvironment of epithelial cancers
Areas of Research: My lab is focused on the biology of aging, with a particular interest on metabolism, IGF-1 signaling, and the role of cell autonomous and non-cell autonomous mediators of aging phenotypes utilizing heterochronic parabiosis.
Areas of Research: Neurobiology of obesity, Electrophysiological analysis of hypothalamic neurons, Neuronal mapping of feeding-related circuits, Behavioral evaluation of cell type-specific circuit connections using optogenetics
Areas of Research: Role of Microbiome-Host Interactions in Physiology and Disease, Orphan Nuclear Receptors in Physiology and Disease, Gastrointestinal Cancer, Drug Discovery and Development
Areas of Research: Breast, Lung and Ovarian Cancer:
Experimental Therapeutics - Oncology:
Cancer and Senescence:
Intrinsic and Acquired Drug Resistance:
Senolytic Drug Development:
Areas of Research: Ion channel behavior in health and disease with a focus on human genetics, structure/function relationships, epigenetics and regulation of protein translation.
Areas of Research: Regulation of glucose metabolism
Epigenetic modifications regulating metabolism
Regulation of lipogenic gene transcription and de novo lipogenesis
Program cell death
adipocyte and liver biology
Integrative metabolic signaling
Areas of Research: We are interested in studying the roles of autophagy in metabolic regulation in physiology, during obesity, and with age.