Department of Microbiology & Immunology

Fellow publications

 

Riyasat Ali, DiLorenzo Lab 

Babad, J., G. Mukherjee, A. Follenzi, R. Ali, B. O. Roep, L. D. Shultz, P. Santamaria, O. O. Yang, H. Goldstein, D. L. Greiner, and T. P. DiLorenzo. 2015. Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol 179:398-413

 

 

 

Sushma Bharrhan, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

 

 

 

Patrick Bilder, Chan Lab 

Drumm, J. E., K. Mi, P. Bilder, M. Sun, J. Lim, H. Bielefeldt-Ohmann, R. Basaraba, M. So, G. Zhu, J. M. Tufariello, A. A. Izzo, I. M. Orme, S. C. Almo, T. S. Leyh, and J. Chan. 2009. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: requirement for establishing chronic persistent infection. PLoS Pathog 5:e1000460

 

 

 

Fabrizio Biundo, D'Adamio Lab 

Matrone, C., S. Luvisetto, L. R. La Rosa, R. Tamayev, A. Pignataro, N. Canu, L. Yang, A. P. Barbagallo, F. Biundo, F. Lombino, H. Zheng, M. Ammassari-Teule, and L. D'Adamio. 2012. Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell 11:1084-1093

Lombino, F., F. Biundo, R. Tamayev, O. Arancio, and L. D'Adamio. 2013. An intracellular threonine of amyloid-beta precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One 8:e57120

 

 

 

Leandro Carreno, Porcelli Lab 

Wen, X., P. Rao, L. J. Carreno, S. Kim, A. Lawrenczyk, S. A. Porcelli, P. Cresswell, and W. Yuan. 2013. Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc Natl Acad Sci U S A 110:2963-2968

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Carreno, L. J., S. S. Kharkwal, and S. A. Porcelli. 2014. Optimizing NKT cell ligands as vaccine adjuvants. Immunotherapy 6:309-320

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

Prados-Rosales, R., L. J. Carreno, A. Batista-Gonzalez, A. Baena, M. M. Venkataswamy, J. Xu, X. Yu, G. Wallstrom, D. M. Magee, J. LaBaer, J. M. Achkar, W. R. Jacobs, Jr., J. Chan, S. A. Porcelli, and A. Casadevall. 2014. Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis. mBio 5:e01921-01914

Singh, M., W. Quispe-Tintaya, D. Chandra, A. Jahangir, M. M. Venkataswamy, T. W. Ng, S. Sharma-Kharkwal, L. J. Carreno, S. A. Porcelli, and C. Gravekamp. 2014. Direct incorporation of the NKT-cell activator alpha-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy. Br J Cancer 111:1945-1954

 

 

 

Laurent Chorro, Lauvau Lab 

Lauvau, G., L. Chorro, E. Spaulding, and S. M. Soudja. 2014. Inflammatory monocyte effector mechanisms. Cell Immunol 291:32-40

 

 

 

Ian Cook, Leyh Lab 

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation. Horm Mol Biol Clin Investig 1:81-87

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1. Horm Mol Biol Clin Investig 3:357-366

Rohn, K. J., I. T. Cook, T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2012. Potent inhibition of human sulfotransferase 1A1 by 17alpha-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos 40:1588-1595

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2012. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry 51:5674-5683

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. The gate that governs sulfotransferase selectivity. Biochemistry 52:415-424

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. Testing the sulfotransferase molecular pore hypothesis. J Biol Chem 288:8619-8626

Leyh, T. S., I. Cook, and T. Wang. 2013. Structure, dynamics and selectivity in the sulfotransferase family. Drug Metab Rev 45:423-430

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2013. High accuracy in silico sulfotransferase models. J Biol Chem 288:34494-34501

Wang, T., I. Cook, C. N. Falany, and T. S. Leyh. 2014. Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1. J Biol Chem 289:26474-26480

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2015. The allosteric binding sites of sulfotransferase 1A1. Drug Metab Dispos 43:418-423

Wang, T., I. Cook, and T. S. Leyh. 2014. 3'-Phosphoadenosine 5'-phosphosulfate allosterically regulates sulfotransferase turnover. Biochemistry 53:6893-6900

 

 

 

Dolores Del Prete, D'Adamio Lab 

Del Prete, D., F. Lombino, X. Liu, and L. D'Adamio. 2014. APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions. PLoS One 9:e108576

 

 

 

Susan Irvin, Herold Lab 

Murphy, K., S. C. Irvin, and B. C. Herold. 2014. Research gaps in defining the biological link between HIV risk and hormonal contraception. Am J Reprod Immunol 72:228-235

Irvin, S. C., and B. C. Herold. 2015. Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk. PLoS One 10:e0121135

Costantini, L. M., S. C. Irvin, S. C. Kennedy, F. Guo, H. Goldstein, B. C. Herold, and E. L. Snapp. 2015. Engineering and exploitation of a fluorescent HIV-1 gp120 for live cell CD4 binding assays. Virology 476:240-248

 

 

 

Murali Janakiram, Zang Lab 

Janakiram, M., Y. M. Abadi, J. A. Sparano, and X. Zang. 2012. T cell coinhibition and immunotherapy in human breast cancer. Discov Med 14:229-236

Jeon, H., V. Vigdorovich, S. C. Garrett-Thomson, M. Janakiram, U. A. Ramagopal, Y. M. Abadi, J. S. Lee, L. Scandiuzzi, K. C. Ohaegbulam, J. M. Chinai, R. Zhao, Y. Yao, Y. Mao, J. A. Sparano, S. C. Almo, and X. Zang. 2014. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 9:1089-1098

Janakiram, M., J. M. Chinai, S. Fineberg, A. Fiser, C. Montagna, R. Medavarapu, E. Castano, H. Jeon, K. C. Ohaegbulam, R. Zhao, A. Zhao, S. C. Almo, J. A. Sparano, and X. Zang. 2015. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin Cancer Res 21:2359-2366

Chinai, J. M., M. Janakiram, F. Chen, W. Chen, M. Kaplan, and X. Zang. 2015. New immunotherapies targeting the PD-1 pathway. Trends Pharmacol Sci (in press)

 

 

 

Rohit Jangra, Chandran Lab 

Ng, M., E. Ndungo, R. K. Jangra, Y. Cai, E. Postnikova, S. R. Radoshitzky, J. M. Dye, E. Ramirez de Arellano, A. Negredo, G. Palacios, J. H. Kuhn, and K. Chandran. 2014. Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1. Virology 468-470:637-646

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

 

 

 

Alison Johnson, Porcelli Lab 

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

 

 

 

Joseph Katakowski, Palliser Lab 

Katakowski, J. A., and D. Palliser. 2010. siRNA-based topical microbicides targeting sexually transmitted infections. Curr Opin Mol Ther 12:192-202

Katakowski, J. A., and D. Palliser. 2011. Optimizing siRNA delivery to the genital mucosa. Discov Med 11:124-132

Wengerter, B. C., J. A. Katakowski, J. M. Rosenberg, C. G. Park, S. C. Almo, D. Palliser, and M. Levy. 2014. Aptamer-targeted antigen delivery. Mol Ther 22:1375-1387

Tosti, E., J. A. Katakowski, S. Schaetzlein, H. S. Kim, C. J. Ryan, M. Shales, A. Roguev, N. J. Krogan, D. Palliser, M. C. Keogh, and W. Edelmann. 2014. Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. Genome Med 6:68

 

 

 

Shajo Kunnath Velayudhan, Porcelli Lab 

Kunnath-Velayudhan, S., and S. A. Porcelli. 2013. Recent advances in defining the immunoproteome of Mycobacterium tuberculosis. Front Immunol 4:335

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

 

 

 

Adel Malek, Jacobs Lab 

Tufariello, J. M., A. A. Malek, C. Vilcheze, L. E. Cole, H. K. Ratner, P. A. Gonzalez, P. Jain, G. F. Hatfull, M. H. Larsen, and W. R. Jacobs, Jr. 2014. Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis. mBio 5:e01179-01114

 

 

 

Simren Mehta, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

 

 

 

Eva Mittler, Chandran Lab 

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

 

 

 

Silvana Opp, Diaz-Griffero Lab 

Fricke, T., C. Buffone, S. Opp, J. Valle-Casuso, and F. Diaz-Griffero. 2014. BI-2 destabilizes HIV-1 cores during infection and prevents binding of CPSF6 to the HIV-1 capsid. Retrovirology 11:120

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

 

 

 

Neeraj Saini, Porcelli Lab 

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Goldberg, M. F., N. K. Saini, and S. A. Porcelli. 2014. Evasion of innate and adaptive immunity by Mycobacterium tuberculosis. Microbiol Spectr 2

 

 

 

Bianca Schulte, Diaz-Griffero Lab 

Fricke, T., T. E. White, B. Schulte, D. A. de Souza Aranha Vieira, A. Dharan, E. M. Campbell, A. Brandariz-Nunez, and F. Diaz-Griffero. 2014. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology 11:68

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

Malikov, V., E. S. da Silva, V. Jovasevic, G. Bennett, D. A. de Souza Aranha Vieira, B. Schulte, F. Diaz-Griffero, D. Walsh, and M. H. Naghavi. 2015. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun 6:6660

 

 

 

Shalu Sharma, Porcelli Lab 

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Carreno, L. J., S. S. Kharkwal, and S. A. Porcelli. 2014. Optimizing NKT cell ligands as vaccine adjuvants. Immunotherapy 6:309-320

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

Singh, M., W. Quispe-Tintaya, D. Chandra, A. Jahangir, M. M. Venkataswamy, T. W. Ng, S. Sharma-Kharkwal, L. J. Carreno, S. A. Porcelli, and C. Gravekamp. 2014. Direct incorporation of the NKT-cell activator alpha-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy. Br J Cancer 111:1945-1954

 

 

 

Arti Shinde, Frangogiannis Lab 

Gonzalez-Quesada, C., M. Cavalera, A. Biernacka, P. Kong, D. W. Lee, A. Saxena, O. Frunza, M. Dobaczewski, A. Shinde, and N. G. Frangogiannis. 2013. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 113:1331-1344

Shinde, A. V., and N. G. Frangogiannis. 2014. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 70:74-82

Biernacka, A., M. Cavalera, J. Wang, I. Russo, A. Shinde, P. Kong, C. Gonzalez-Quesada, V. Rai, M. Dobaczewski, D. W. Lee, X. F. Wang, and N. G. Frangogiannis. 2015. Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 8:788-798

Shinde, A. V., and N. G. Frangogiannis. 2015. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium. Circ Res 117:10-12

 

 

 

Natalie Silmon de Monerri, Kim Lab 

Nardelli, S. C., F. Y. Che, N. C. Silmon de Monerri, H. Xiao, E. Nieves, C. Madrid-Aliste, S. O. Angel, W. J. Sullivan, Jr., R. H. Angeletti, K. Kim, and L. M. Weiss. 2013. The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications. mBio 4:e00922-00913

Silmon de Monerri, N. C., and K. Kim. 2014. Pathogens hijack the epigenome: a new twist on host-pathogen interactions. Am J Pathol 184:897-911

 

 

 

Sangeeta Tiwari, Jacobs Lab 

Junqueira-Kipnis, A. P., F. M. de Oliveira, M. M. Trentini, S. Tiwari, B. Chen, D. P. Resende, B. D. Silva, M. Chen, L. Tesfa, W. R. Jacobs, Jr., and A. Kipnis. 2013. Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis. PLoS One 8:e78639

Vilcheze, C., V. Molle, S. Carrere-Kremer, J. Leiba, L. Mourey, S. Shenai, G. Baronian, J. Tufariello, T. Hartman, R. Veyron-Churlet, X. Trivelli, S. Tiwari, B. Weinrick, D. Alland, Y. Guerardel, W. R. Jacobs, Jr., and L. Kremer. 2014. Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis. PLoS Pathog 10:e1004115

Zolla, V., I. T. Nizamutdinova, B. Scharf, C. C. Clement, D. Maejima, T. Akl, T. Nagai, P. Luciani, J. C. Leroux, C. Halin, S. Stukes, S. Tiwari, A. Casadevall, W. R. Jacobs, Jr., D. Entenberg, D. C. Zawieja, J. Condeelis, D. R. Fooksman, A. A. Gashev, and L. Santambrogio. 2015. Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging Cell 14:582-594

 

 

 

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