Department of Microbiology & Immunology

Fellow publications

 

Fabrizio Biundo, D'Adamio Lab 

Matrone, C., S. Luvisetto, L. R. La Rosa, R. Tamayev, A. Pignataro, N. Canu, L. Yang, A. P. Barbagallo, F. Biundo, F. Lombino, H. Zheng, M. Ammassari-Teule, and L. D'Adamio. 2012. Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell 11:1084-1093

Lombino, F., F. Biundo, R. Tamayev, O. Arancio, and L. D'Adamio. 2013. An intracellular threonine of amyloid-beta precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One 8:e57120

 

 

 

Leandro Carreno, Porcelli Lab 

Wen, X., P. Rao, L. J. Carreno, S. Kim, A. Lawrenczyk, S. A. Porcelli, P. Cresswell, and W. Yuan. 2013. Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc Natl Acad Sci U S A 110:2963-2968

 

 

 

Ian Cook, Leyh Lab 

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation. Horm Mol Biol Clin Investig 1:81-87

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1. Horm Mol Biol Clin Investig 3:357-366

Rohn, K. J., I. T. Cook, T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2012. Potent inhibition of human sulfotransferase 1A1 by 17alpha-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos 40:1588-1595

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2012. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry 51:5674-5683

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. The gate that governs sulfotransferase selectivity. Biochemistry 52:415-424

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. Testing the sulfotransferase molecular pore hypothesis. J Biol Chem 288:8619-8626

 

 

 

Travis Hartman, Jacobs Lab 

Vilcheze, C., T. Hartman, B. Weinrick, and W. R. Jacobs, Jr. 2013. Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction. Nat Commun 4:1881

Jain, P., T. E. Hartman, N. Eisenberg, M. R. O'Donnell, J. Kriakov, K. Govender, M. Makume, D. S. Thaler, G. F. Hatfull, A. W. Sturm, M. H. Larsen, P. Moodley, and W. R. Jacobs, Jr. 2012. Φ2GFP10, a high-intensity fluorophage, enables detection and rapid drug susceptibility testing of Mycobacterium tuberculosis directly from sputum samples. J Clin Microbiol 50:1362-1369

 
 
 

Murali Janakiram, Zang Lab 

Janakiram, M., Y. M. Abadi, J. A. Sparano, and X. Zang. 2012. T cell coinhibition and immunotherapy in human breast cancer. Discov Med 14:229-236

 
 
 

Thomas Jandl, Dadachova Lab 

Revskaya, E., P. Chu, R. C. Howell, A. D. Schweitzer, R. A. Bryan, M. Harris, G. Gerfen, Z. Jiang, T. Jandl, K. Kim, L. M. Ting, R. S. Sellers, E. Dadachova, and A. Casadevall. 2012. Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation. Cancer Biother Radiopharm 27:570-576

Jandl, T., E. Revskaya, Z. Jiang, M. Harris, O. Dorokhova, D. Tsukrov, A. Casadevall, and E. Dadachova. 2013. Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy. Nucl Med Biol 40:177-181

Jandl, T., E. Revskaya, Z. Jiang, R. A. Bryan, A. Casadevall, and E. Dadachova. 2013. Complement-dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma. Immunotherapy 5:357-364

 
 
 

Hyungjun Jeon, Zang Lab 

Hofmeyer, K. A., H. Jeon, and X. Zang. 2011. The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol 2011:451694

Abadi, Y. M., H. Jeon, K. C. Ohaegbulam, L. Scandiuzzi, K. Ghosh, K. A. Hofmeyer, J. S. Lee, A. Ray, C. Gravekamp, and X. Zang. 2013. Host B7x promotes pulmonary metastasis of breast cancer. J Immunol 190:3806-3814

Zhao, R., J. M. Chinai, S. Buhl, L. Scandiuzzi, A. Ray, H. Jeon, K. C. Ohaegbulam, K. Ghosh, A. Zhao, M. D. Scharff, and X. Zang. 2013. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proc Natl Acad Sci U S A 110:9879-9884

 
 
 

Saidi M'Homa Soudja, Lauvau Lab 

Campisi, L., S. M. Soudja, J. Cazareth, D. Bassand, A. Lazzari, F. Brau, E. Narni-Mancinelli, N. Glaichenhaus, F. Geissmann, and G. Lauvau. 2011. Splenic CD8α dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8 T-cell memory. Eur J Immunol 41:1594-1605

Narni-Mancinelli, E., S. M. Soudja, K. Crozat, M. Dalod, P. Gounon, F. Geissmann, and G. Lauvau. 2011. Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo. PLoS Pathog 7:e1002457

Soudja, S. M., A. L. Ruiz, J. C. Marie, and G. Lauvau. 2012. Inflammatory monocytes activate memory CD8+ T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasion. Immunity 37:549-562

 
 
 

Pedro Mesquita, Herold Lab 

Madan, R. P., P. M. Mesquita, N. Cheshenko, B. Jing, V. Shende, E. Guzman, T. Heald, M. J. Keller, S. L. Regen, R. J. Shattock, and B. C. Herold. 2007. Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infections. J Virol 81:7636-7646

Fakioglu, E., S. S. Wilson, P. M. Mesquita, E. Hazrati, N. Cheshenko, J. A. Blaho, and B. C. Herold. 2008. Herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion mechanism. J Virol 82:9337-9344

Mesquita, P. M., S. S. Wilson, P. Manlow, L. Fischetti, M. J. Keller, B. C. Herold, and R. J. Shattock. 2008. Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. J Virol 82:6576-6584

Mesquita, P. M., N. Cheshenko, S. S. Wilson, M. Mhatre, E. Guzman, E. Fakioglu, M. J. Keller, and B. C. Herold. 2009. Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. J Infect Dis 200:599-608

Wilson, S. S., N. Cheshenko, E. Fakioglu, P. M. Mesquita, M. J. Keller, and B. C. Herold. 2009. Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety. Antivir Ther 14:1113-1124

Keller, M. J., P. M. Mesquita, N. M. Torres, S. Cho, G. Shust, R. P. Madan, H. W. Cohen, J. Petrie, T. Ford, L. Soto-Torres, A. T. Profy, and B. C. Herold. 2010. Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials. PLoS One 5:e8781.

Herold, B. C., P. M. Mesquita, R. P. Madan, and M. J. Keller. 2011. Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections. Am J Reprod Immunol 65:325-333

Keller, M. J., R. P. Madan, N. M. Torres, M. J. Fazzari, S. Cho, S. Kalyoussef, G. Shust, P. M. Mesquita, N. Louissaint, J. Chen, H. W. Cohen, E. C. Diament, A. C. Lee, L. Soto-Torres, C. W. Hendrix, and B. C. Herold. 2011. A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel. PLoS One 6:e16475

Segarra, T. J., E. Fakioglu, N. Cheshenko, S. S. Wilson, P. M. Mesquita, G. F. Doncel, and B. C. Herold. 2011. Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety. PLoS One 6:e27675

Mesquita, P. M., R. Rastogi, T. J. Segarra, R. S. Teller, N. M. Torres, A. M. Huber, P. F. Kiser, and B. C. Herold. 2012. Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection. J Antimicrob Chemother 67:1730-1738

Kiser, P. F., P. M. Mesquita, and B. C. Herold. 2012. A perspective on progress and gaps in HIV prevention science. AIDS Res Hum Retroviruses 28:1373-1378

Nixon, B., M. Stefanidou, P. M. Mesquita, E. Fakioglu, T. Segarra, L. Rohan, W. Halford, K. E. Palmer, and B. C. Herold. 2013. Griffithsin protects mice from genital herpes by preventing cell-to-cell spread. J Virol 87:6257-6269

 
 
 

Ekaterina Revskaya, Dadachova Lab 

Dadachova, E., R. A. Bryan, C. Apostolidis, A. Morgenstern, T. Zhang, T. Moadel, M. Torres, X. Huang, E. Revskaya, and A. Casadevall. 2006. Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection. J Infect Dis 193:1427-1436

Dadachova, E., T. Moadel, A. D. Schweitzer, R. A. Bryan, T. Zhang, L. Mints, E. Revskaya, X. Huang, G. Ortiz, J. S. Nosanchuk, J. D. Nosanchuk, and A. Casadevall. 2006. Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease. Cancer Biother Radiopharm 21:117-129

Howell, R. C., E. Revskaya, V. Pazo, J. D. Nosanchuk, A. Casadevall, and E. Dadachova. 2007. Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma. Bioconjug Chem 18:1739-1748

Schweitzer, A. D., V. Rakesh, E. Revskaya, A. Datta, A. Casadevall, and E. Dadachova. 2007. Computational model predicts effective delivery of 188-Re-labeled melanin-binding antibody to metastatic melanoma tumors with wide range of melanin concentrations. Melanoma Res 17:291-303

Wang, X. G., E. Revskaya, R. A. Bryan, H. D. Strickler, R. D. Burk, A. Casadevall, and E. Dadachova. 2007. Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. PLoS One 2:e1114

Dadachova, E., E. Revskaya, M. A. Sesay, H. Damania, R. Boucher, R. S. Sellers, R. C. Howell, L. Burns, G. B. Thornton, A. Natarajan, G. R. Mirick, S. J. DeNardo, G. L. DeNardo, and A. Casadevall. 2008. Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice. Cancer Biol Ther 7:1116-1127

Dadachova, E., J. Rivera, E. Revskaya, A. Nakouzi, S. M. Cahill, M. Blumenstein, H. Xiao, D. Rykunov, and A. Casadevall. 2008. In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins. Nucl Med Biol 35:755-761

Revskaya, E., A. M. Jongco, R. S. Sellers, R. C. Howell, W. Koba, A. J. Guimaraes, J. D. Nosanchuk, A. Casadevall, and E. Dadachova. 2009. Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine. Clin Cancer Res 15:2373-2379

Rivera, J., A. Nakouzi, N. Abboud, E. Revskaya, D. Goldman, R. J. Collier, E. Dadachova, and A. Casadevall. 2006. A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun 74:4149-4156.

Schweitzer, A. D., E. Revskaya, P. Chu, V. Pazo, M. Friedman, J. D. Nosanchuk, S. Cahill, S. Frases, A. Casadevall, and E. Dadachova. 2010. Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer. Int J Radiat Oncol Biol Phys 78:1494-1502

Ballard, B., Z. Jiang, C. E. Soll, E. Revskaya, C. S. Cutler, E. Dadachova, and L. C. Francesconi. 2011. In vitro and in vivo evaluation of melanin-binding decapeptide 4B4 radiolabeled with 177Lu, 166Ho, and 153Sm radiolanthanides for the purpose of targeted radionuclide therapy of melanoma. Cancer Biother Radiopharm 26:547-556

Dadachova, E., S. G. Kitchen, G. Bristol, G. C. Baldwin, E. Revskaya, C. Empig, G. B. Thornton, M. K. Gorny, S. Zolla-Pazner, and A. Casadevall. 2012. Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication. PLoS One 7:e31866

Revskaya, E., P. Chu, R. C. Howell, A. D. Schweitzer, R. A. Bryan, M. Harris, G. Gerfen, Z. Jiang, T. Jandl, K. Kim, L. M. Ting, R. S. Sellers, E. Dadachova, and A. Casadevall. 2012. Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation. Cancer Biother Radiopharm 27:570-576

Jandl, T., E. Revskaya, Z. Jiang, M. Harris, O. Dorokhova, D. Tsukrov, A. Casadevall, and E. Dadachova. 2013. Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy. Nucl Med Biol 40:177-181

Klein, M., M. Lotem, T. Peretz, S. T. Zwas, S. Mizrachi, Y. Liberman, R. Chisin, J. Schachter, I. G. Ron, G. Iosilevsky, J. A. Kennedy, E. Revskaya, A. W. de Kater, E. Banaga, V. Klutzaritz, N. Friedmann, E. Galun, G. L. Denardo, S. J. Denardo, A. Casadevall, E. Dadachova, and G. B. Thornton. 2013. Safety and efficacy of 188-rhenium-labeled antibody to melanin in patients with metastatic melanoma. J Skin Cancer 2013:828329

Jandl, T., E. Revskaya, Z. Jiang, R. A. Bryan, A. Casadevall, and E. Dadachova. 2013. Complement-dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma. Immunotherapy 5:357-364

 
 
 

Martha Stefanidou, Herold Lab 

Patel, M., M. Stefanidou, C. B. Long, M. J. Fazzari, L. Tesfa, M. Del Rio, J. Lamour, R. Ricafort, R. P. Madan, and B. C. Herold. 2011. Dynamics of cell-mediated immune responses to cytomegalovirus in pediatric transplantation recipients. Pediatr Transplant 16:18-28

Stefanidou, M., I. Ramos, V. Mas Casullo, J. B. Trepanier, S. Rosenbaum, A. Fernandez-Sesma, and B. C. Herold. 2013. Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy. J Virol 87:1443-1453

Nixon, B., M. Stefanidou, P. M. Mesquita, E. Fakioglu, T. Segarra, L. Rohan, W. Halford, K. E. Palmer, and B. C. Herold. 2013. Griffithsin protects mice from genital herpes by preventing cell-to-cell spread. J Virol 87:6257-6269

Cheshenko, N., J. B. Trepanier, M. Stefanidou, N. Buckley, P. Gonzalez, W. Jacobs, and B. C. Herold. 2013. HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression. FASEB J in press

 
 
 

Wendy Szymczak, Pirofski Lab 

Szymczak, W. A., R. S. Sellers, and L. A. Pirofski. 2012. IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms. Am J Pathol 180:1547-1559

 
 
 

Zoi Tampaki, Kim Lab 

Joyce, B. R., Z. Tampaki, K. Kim, R. C. Wek, and W. J. Sullivan, Jr. 2013. The Unfolded Protein Response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control. Eukaryot Cell in press

 
 
 

Avanish Varshney, Fries Lab 

Varshney, A. K., J. R. Mediavilla, N. Robiou, A. Guh, X. Wang, P. Gialanella, M. Levi, B. N. Kreiswirth, and B. C. Fries. 2009. Diverse enterotoxin gene profiles among clonal complexes of Staphylococcus aureus isolates from the Bronx. Appl Environ Microbiol 75:6839-6849

Varshney, A. K., L. R. Martinez, S. M. Hamilton, A. E. Bryant, M. H. Levi, P. Gialanella, D. L. Stevens, and B. C. Fries. 2010. Augmented production of Panton-Valentine leukocidin toxin in methicillin-resistant and methicillin-susceptible Staphylococcus aureus is associated with worse outcome in a murine skin infection model. J Infect Dis 201:92-96

Varshney, A. K., X. Wang, E. Cook, K. Dutta, M. D. Scharff, M. J. Goger, and B. C. Fries. 2011. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. J Biol Chem 286:9737-9747

Kaltsas, A., A. Guh, J. R. Mediavilla, A. K. Varshney, N. Robiou, P. Gialanellia, M. Henry, M. H. Levi, and B. C. Fries. 2011. Frequency of Panton-Valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in Bronx, New York. J Clin Microbiol 49:2992-2995

Schwechter, E. M., D. Folk, A. K. Varshney, B. C. Fries, S. J. Kim, and D. M. Hirsh. 2011. Optimal irrigation and debridement of infected joint implants: an in vitro methicillin-resistant Staphylococcus aureus biofilm model. J Arthroplasty 26:109-113

 
 
 

Ting Wang, Leyh Lab 

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2012. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry 51:5674-5683

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. The gate that governs sulfotransferase selectivity. Biochemistry 52:415-424

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. Testing the sulfotransferase molecular pore hypothesis. J Biol Chem 288:8619-8626

Wang, T., and T. S. Leyh. 2012. Three-stage assembly of the cysteine synthase complex from Escherichia coli. J Biol Chem 287:4360-4367

 
 
 

Julie Wolf, Casadevall Lab 

Wolf, J. M., J. Rivera, and A. Casadevall. 2012. Serum albumin disrupts Cryptococcus neoformans and Bacillus anthracis extracellular vesicles. Cell Microbiol 14:762-773

Robertson, E. J., J. M. Wolf, and A. Casadevall. 2012. EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by Cryptococcus neoformans. Appl Environ Microbiol 78:7977-7984

 
 
 
Click here to log in