Department of Microbiology & Immunology

Fellow publications

 

Linda Alex, Frangogiannis Lab 

Hanif, W., L. Alex, Y. Su, A. V. Shinde, I. Russo, N. Li, and N. G. Frangogiannis. 2017. Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure. Cardiovasc Pathol 30: 27-37

 

 

 

Riyasat Ali, DiLorenzo Lab 

Babad, J., R. Ali, J. Schloss, and T. P. DiLorenzo. 2016. An HLA-transgenic mouse model of type 1 diabetes that incorporates the reduced, but not abolished, thymic insulin expression seen in patients. J. Diabetes Res 2016:7959060

Ali, R., J. Babad, A. Follenzi, J. A. Gebe, M. A. Brehm, G. T. Nepom, L. D. Shultz, D. L. Greiner, and T. P. DiLorenzo. 2016. Genetically modified human CD4+ T cells can be evaluated in vivo without lethal graft versus host disease. Immunology 148: 339-351

Babad, J., G. Mukherjee, A. Follenzi, R. Ali, B. O. Roep, L. D. Shultz, P. Santamaria, O. O. Yang, H. Goldstein, D. L. Greiner, and T. P. DiLorenzo. 2015. Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol 179:398-413

 

 

 

Sushma Bharrhan, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

 

 

 

Marie Boutet, Lauvau Lab 

Lauvau, G., M. Boutet, T. M. Williams, S. S. Chin, and L. Chorro. 2016. Memory CD8+ T cells: Innate-like sensors and orchestrators of protection. Trends Immunol 37: 375-385

 

 

 

Samantha Chalmers, Putterman Lab 

Pawar, R. D., B. Goilav, Y. Xia, L. Herlitz, J. Doerner, S. Chalmers, K. Ghosh, X. Zang, and C. Putterman. 2014. B7x/B7H-4 modulates the adaptive immune response and ameliorates renal injury in antibody mediated nephritis. Clin Exp Immunol 179:329-343

Chalmers, S. A., V. Chitu, L. C. Herlitz, R. Sahu, E. R. Stanley, and C. Putterman. 2015. Macrophage depletion ameliorates nephritis induced by pathogenic antibodies. J Autoimmun 57:42-52

Doerner, J. L., J. Wen, Y. Xia, K. B. Paz, D. Schairer, L. Wu, S. A. Chalmers, P. Izmirly, J. S. Michaelson, L. C. Burkly, A. J. Friedman, and C. Putterman. 2015. TWEAK/Fn14 signaling involvement in the pathogenesis of cutaneous disease in the MRL/lpr model of spontaneous lupus. J Invest Dermatol 135: 1986-1995

Chalmers, S. A., V. Chitu, M. Ramanujam, and C. Putterman. 2015. Therapeutic targeting of macrophages in lupus nephritis. Discov Med 20: 43-49

Chalmers, S. A., J. Doerner, T. Bosanac, S. Khalil, D. Smith, C. Harcken, J. Dimock, E. Der, L. Herlitz, D. Webb, E. Seccareccia, D. Feng, J. S. Fine, M. Ramanujam, E. Klein, and C. Putterman. 2016. Therapeutic blockade of immune complex-mediated glomerulonephritis by highly selective inhibition of Bruton's tyrosine kinase. Sci Rep 6: 26164

Chalmers, S. A., J. Wen, J. Shum, J. Doerner, L. Herlitz, and C. Putterman. 2016. CSF-1R inhibition attenuates renal and neuropsychiatric disease in murine lupus. Clin Immunol

Doerner, J., S. A. Chalmers, A. Friedman, and C. Putterman. 2016. Fn14 deficiency protects lupus-prone mice from histological lupus erythematosus-like skin inflammation induced by ultraviolet light. Exp Dermatol 25: 969-976

Wen, J., J. Doerner, S. Chalmers, A. Stock, H. Wang, M. Gullinello, M. J. Shlomchik, and C. Putterman. 2016. B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus. J Neuroinflammation 13: 73

Wen, J., A. D. Stock, S. A. Chalmers, and C. Putterman. 2016. The role of B cells and autoantibodies in neuropsychiatric lupus. Autoimmun Rev 15: 890-895

 

 

 

Bijun Chen, Frangogiannis Lab 

Chen, B., and N. G. Frangogiannis. 2016. Macrophages in the remodeling failing heart. Circ Res 119: 776-778

Chen, B., and N. G. Frangogiannis. 2017. Immune cells in repair of the infarcted myocardium. Microcirculation 24

 

 

 

Tingting Chen, Achkar Lab 

Chen, T., C. Blanc, A. Z. Eder, R. Prados-Rosales, A. C. Souza, R. S. Kim, A. Glatman-Freedman, M. Joe, Y. Bai, T. L. Lowary, R. Tanner, M. J. Brennan, H. A. Fletcher, H. McShane, A. Casadevall, and J. M. Achkar. 2016. Association of human antibodies to arabinomannan with enhanced mycobacterial opsonophagocytosis and intracellular growth reduction. J Infect Dis 214: 300-310

 

 

 

Mandy (Shu Shien) Chin, Lauvau Lab 

Lauvau, G., M. Boutet, T. M. Williams, S. S. Chin, and L. Chorro. 2016. Memory CD8+ T cells: Innate-like sensors and orchestrators of protection. Trends Immunol 37: 375-385

 

 

 

Christopher Doyle, Pirofski Lab 

Doyle, C. R., and L. A. Pirofski. 2016. eduction of Streptococcus pneumoniae colonization and dissemination by a nonopsonic capsular polysaccharide antibody. mBio 7: e02260-02215

 

 

 

Raquel Furtado, Lauvau Lab 

Magalhaes, M. L., M. Byrom, A. Yan, L. Kelly, N. Li, R. Furtado, D. Palliser, A. D. Ellington, and M. Levy. 2012. A general RNA motif for cellular transfection. Mol Ther 20: 616-624

Brojatsch, J., H. Lima, Jr., D. Palliser, L. S. Jacobson, S. M. Muehlbauer, R. Furtado, D. L. Goldman, M. P. Lisanti, and K. Chandran. 2015. Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents. Cell Cycle 14: 964-972

 

 

 

Inessa Gendlina, Kim Lab 

Ames, R. Y., L. M. Ting, I. Gendlina, K. Kim, and F. Macian. 2017. The transcription factor NFAT1 participates in the induction of CD4+ T cell functional exhaustion during Plasmodium yoelii infection. Infect Immun

 

 

 

Ana Gradissimo, Burk Lab 

Novetsky, A. P., M. J. Keller, A. Gradissimo, Z. Chen, S. L. Morgan, X. Xue, H. D. Strickler, J. A. Fernandez-Romero, R. Burk, and M. H. Einstein. 2016 In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel. Gynecol Oncol 143: 313-318

Gradissimo, A., and R. D. Burk. 2017. Molecular tests potentially improving HPV screening and genotyping for cervical cancer prevention. Expert Rev Mol Diagn 17: 379-391

 

 

 

Claudio Humeres, Frangogiannis Lab 

Frunza, O., I. Russo, A. Saxena, A. V. Shinde, C. Humeres, W. Hanif, V. Rai, Y. Su, and N. G. Frangogiannis. 2016. Myocardial galectin-3 expression is associated with remodeling of the pressure-overloaded heart and may delay the hypertrophic response without affecting survival, dysfunction, and cardiac fibrosis. Am J Pathol 186: 1114-1127

Shinde, A. V., C. Humeres, and N. G. Frangogiannis. 2017. The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim Biophys Acta 1863: 298-309

 

 

 

Lina Kaminski, Jacobs Lab 

Saito, K., T. Warrier, S. Somersan-Karakaya, L. Kaminski, J. Mi, X. Jiang, S. Park, K. Shigyo, B. Gold, J. Roberts, E. Weber, W. R. Jacobs, Jr., and C. F. Nathan. 2017. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proc Natl Acad Sci USA 114: E4832-E4840

 

 

 

Alicia Martinez Lopez, Diaz-Griffero Lab 

White, T. E., A. Brandariz-Nunez, A. Martinez-Lopez, C. Knowlton, G. Lenzi, B. Kim, D. Ivanov, and F. Diaz-Griffero. 2017. A SAMHD1 mutation associated with Aicardi-Goutieres syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans. Hum Mutat 38: 658-668

 

 

 

Simren Mehta, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

Glass, L. N., G. Swapna, S. S. Chavadi, J. M. Tufariello, K. Mi, J. E. Drumm, T. T. Lam, G. Zhu, C. Zhan, C. Vilcheze, J. Arcos, Y. Chen, L. Bi, S. Mehta, S. A. Porcelli, S. C. Almo, S. R. Yeh, W. R. Jacobs, Jr., J. B. Torrelles, and J. Chan. 2017. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth. PLoS Pathog 13: e1006515

 

 

 

Neida Mita Mendoza, Daily Lab 

Feintuch, C. M., A. Saidi, K. Seydel, G. Chen, A. Goldman-Yassen, N. K. Mita-Mendoza, R. S. Kim, P. S. Frenette, T. Taylor, and J. P. Daily. 2016. Activated neutrophils are associated with pediatric cerebral malaria vasculopathy in Malawian children. mBio 7: e01300-01315

 

 

 

Eva Mittler, Chandran Lab 

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

Spence, J. S., T. B. Krause, E. Mittler, R. K. Jangra, and K. Chandran. 2016. Direct visualization of Ebola virus fusion triggering in the endocytic pathway. mBio 7: e01857-01815

Wec, A. Z., E. K. Nyakatura, A. S. Herbert, K. A. Howell, F. W. Holtsberg, R. R. Bakken, E. Mittler, J. R. Christin, S. Shulenin, R. K. Jangra, S. Bharrhan, A. I. Kuehne, Z. A. Bornholdt, A. I. Flyak, E. O. Saphire, J. E. Crowe, Jr., M. J. Aman, J. M. Dye, J. R. Lai, and K. Chandran. 2016. A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses. Science 354: 350-354

 

 

 

Elodie Picarda, Zang Lab 

Picarda, E., K. C. Ohaegbulam, and X. Zang. 2016. Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy. Clin Cancer Res 22: 3425-3431

 

 

 

Ilaria Russo, Frangogiannis Lab 

Biernacka, A., M. Cavalera, J. Wang, I. Russo, A. Shinde, P. Kong, C. Gonzalez-Quesada, V. Rai, M. Dobaczewski, D. W. Lee, X. F. Wang, and N. G. Frangogiannis. 2015. Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 8: 788-798

Frunza, O., I. Russo, A. Saxena, A. V. Shinde, C. Humeres, W. Hanif, V. Rai, Y. Su, and N. G. Frangogiannis. 2016. Myocardial galectin-3 expression is associated with remodeling of the pressure-overloaded heart and may delay the hypertrophic response without affecting survival, dysfunction, and cardiac fibrosis. Am J Pathol 186: 1114-1127

Russo, I., and N. G. Frangogiannis. 2016. Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol 90: 84-93

Saxena, A., I. Russo, and N. G. Frangogiannis. 2016. Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res 167: 152-166

Hanif, W., L. Alex, Y. Su, A. V. Shinde, I. Russo, N. Li, and N. G. Frangogiannis. 2017. Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure. Cardiovasc Pathol 30: 27-37

 

 

 

Bianca Schulte, Diaz-Griffero Lab 

Fricke, T., T. E. White, B. Schulte, D. A. de Souza Aranha Vieira, A. Dharan, E. M. Campbell, A. Brandariz-Nunez, and F. Diaz-Griffero. 2014. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology 11:68

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

Malikov, V., E. S. da Silva, V. Jovasevic, G. Bennett, D. A. de Souza Aranha Vieira, B. Schulte, F. Diaz-Griffero, D. Walsh, and M. H. Naghavi. 2015. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun 6:6660

Opp, S., D. A. Vieira, B. Schulte, S. K. Chanda, and F. Diaz-Griffero. 2015. MxB is not responsible for the blocking of HIV-1 infection observed in alpha interferon-treated cells. J Virol 90: 3056-3064

 

 

 

Benson Selvanesan, Gravekamp Lab 

Chandra, D., B. C. Selvanesan, Z. Yuan, S. K. Libutti, W. Koba, A. Beck, K. Zhu, A. Casadevall, E. Dadachova, and C. Gravekamp. 2017. 32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect. Oncotarget 8: 20729-20740

 

 

 

Jennifer Spence, Chandran Lab 

Spence, J. S., T. B. Krause, E. Mittler, R. K. Jangra, and K. Chandran. 2016. Direct visualization of Ebola virus fusion triggering in the endocytic pathway. mBio 7: e01857-01815

Zhao, X., K. A. Howell, S. He, J. M. Brannan, A. Z. Wec, E. Davidson, H. L. Turner, C. I. Chiang, L. Lei, J. M. Fels, H. Vu, S. Shulenin, A. N. Turonis, A. I. Kuehne, G. Liu, M. Ta, Y. Wang, C. Sundling, Y. Xiao, J. S. Spence, B. J. Doranz, F. W. Holtsberg, A. B. Ward, K. Chandran, J. M. Dye, X. Qiu, Y. Li, and M. J. Aman. 2017. Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability. Cell 169: 891-904 e815

 

 

 

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