Department of Microbiology & Immunology

Fellow publications

 

Riyasat Ali, DiLorenzo Lab 

Babad, J., R. Ali, J. Schloss, and T. P. DiLorenzo. 2016. An HLA-transgenic mouse model of type 1 diabetes that incorporates the reduced, but not abolished, thymic insulin expression seen in patients. J. Diabetes Res 2016:7959060

Ali, R., J. Babad, A. Follenzi, J. A. Gebe, M. A. Brehm, G. T. Nepom, L. D. Shultz, D. L. Greiner, and T. P. DiLorenzo. 2016. Genetically modified human CD4+ T cells can be evaluated in vivo without lethal graft versus host disease. Immunology (in press)

Babad, J., G. Mukherjee, A. Follenzi, R. Ali, B. O. Roep, L. D. Shultz, P. Santamaria, O. O. Yang, H. Goldstein, D. L. Greiner, and T. P. DiLorenzo. 2015. Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol 179:398-413

 

 

 

Sushma Bharrhan, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

 

 

 

Patrick Bilder, Chan Lab 

Drumm, J. E., K. Mi, P. Bilder, M. Sun, J. Lim, H. Bielefeldt-Ohmann, R. Basaraba, M. So, G. Zhu, J. M. Tufariello, A. A. Izzo, I. M. Orme, S. C. Almo, T. S. Leyh, and J. Chan. 2009. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: requirement for establishing chronic persistent infection. PLoS Pathog 5:e1000460

 

 

 

Fabrizio Biundo, D'Adamio Lab 

Matrone, C., S. Luvisetto, L. R. La Rosa, R. Tamayev, A. Pignataro, N. Canu, L. Yang, A. P. Barbagallo, F. Biundo, F. Lombino, H. Zheng, M. Ammassari-Teule, and L. D'Adamio. 2012. Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell 11:1084-1093

Lombino, F., F. Biundo, R. Tamayev, O. Arancio, and L. D'Adamio. 2013. An intracellular threonine of amyloid-beta precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One 8:e57120

 

 

 

Laurent Chorro, Lauvau Lab 

Lauvau, G., L. Chorro, E. Spaulding, and S. M. Soudja. 2014. Inflammatory monocyte effector mechanisms. Cell Immunol 291:32-40

 

 

 

Ian Cook, Leyh Lab 

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation. Horm Mol Biol Clin Investig 1:81-87

Cook, I. T., T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2010. Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1. Horm Mol Biol Clin Investig 3:357-366

Rohn, K. J., I. T. Cook, T. S. Leyh, S. A. Kadlubar, and C. N. Falany. 2012. Potent inhibition of human sulfotransferase 1A1 by 17alpha-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos 40:1588-1595

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2012. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry 51:5674-5683

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. The gate that governs sulfotransferase selectivity. Biochemistry 52:415-424

Cook, I., T. Wang, S. C. Almo, J. Kim, C. N. Falany, and T. S. Leyh. 2013. Testing the sulfotransferase molecular pore hypothesis. J Biol Chem 288:8619-8626

Leyh, T. S., I. Cook, and T. Wang. 2013. Structure, dynamics and selectivity in the sulfotransferase family. Drug Metab Rev 45:423-430

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2013. High accuracy in silico sulfotransferase models. J Biol Chem 288:34494-34501

Wang, T., I. Cook, C. N. Falany, and T. S. Leyh. 2014. Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1. J Biol Chem 289:26474-26480

Cook, I., T. Wang, C. N. Falany, and T. S. Leyh. 2015. The allosteric binding sites of sulfotransferase 1A1. Drug Metab Dispos 43:418-423

Wang, T., I. Cook, and T. S. Leyh. 2014. 3'-Phosphoadenosine 5'-phosphosulfate allosterically regulates sulfotransferase turnover. Biochemistry 53:6893-6900

 

 

 

Dolores Del Prete, D'Adamio Lab 

Del Prete, D., F. Lombino, X. Liu, and L. D'Adamio. 2014. APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions. PLoS One 9:e108576

 

 

 

Murali Janakiram, Zang Lab 

Janakiram, M., Y. M. Abadi, J. A. Sparano, and X. Zang. 2012. T cell coinhibition and immunotherapy in human breast cancer. Discov Med 14:229-236

Jeon, H., V. Vigdorovich, S. C. Garrett-Thomson, M. Janakiram, U. A. Ramagopal, Y. M. Abadi, J. S. Lee, L. Scandiuzzi, K. C. Ohaegbulam, J. M. Chinai, R. Zhao, Y. Yao, Y. Mao, J. A. Sparano, S. C. Almo, and X. Zang. 2014. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 9:1089-1098

Janakiram, M., J. M. Chinai, S. Fineberg, A. Fiser, C. Montagna, R. Medavarapu, E. Castano, H. Jeon, K. C. Ohaegbulam, R. Zhao, A. Zhao, S. C. Almo, J. A. Sparano, and X. Zang. 2015. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin Cancer Res 21:2359-2366

Chinai, J. M., M. Janakiram, F. Chen, W. Chen, M. Kaplan, and X. Zang. 2015. New immunotherapies targeting the PD-1 pathway. Trends Pharmacol Sci (in press)

 

 

 

Rohit Jangra, Chandran Lab 

Ng, M., E. Ndungo, R. K. Jangra, Y. Cai, E. Postnikova, S. R. Radoshitzky, J. M. Dye, E. Ramirez de Arellano, A. Negredo, G. Palacios, J. H. Kuhn, and K. Chandran. 2014. Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1. Virology 468-470:637-646

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

 

 

 

Alison Johnson, Porcelli Lab 

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

 

 

 

Shajo Kunnath Velayudhan, Porcelli Lab 

Kunnath-Velayudhan, S., and S. A. Porcelli. 2013. Recent advances in defining the immunoproteome of Mycobacterium tuberculosis. Front Immunol 4:335

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

 

 

 

Adel Malek, Jacobs Lab 

Tufariello, J. M., A. A. Malek, C. Vilcheze, L. E. Cole, H. K. Ratner, P. A. Gonzalez, P. Jain, G. F. Hatfull, M. H. Larsen, and W. R. Jacobs, Jr. 2014. Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis. mBio 5:e01179-01114

 

 

 

Simren Mehta, Chan Lab 

Chan, J., S. Mehta, S. Bharrhan, Y. Chen, J. M. Achkar, A. Casadevall, and J. Flynn. 2014. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol 26:588-600

 

 

 

Eva Mittler, Chandran Lab 

Kleinfelter, L. M., R. K. Jangra, L. T. Jae, A. S. Herbert, E. Mittler, K. M. Stiles, A. S. Wirchnianski, M. Kielian, T. R. Brummelkamp, J. M. Dye, and K. Chandran. 2015. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6

 

 

 

Melinda Ng, Chandran Lab 

Krishnan, A., E. H. Miller, A. S. Herbert, M. Ng, E. Ndungo, S. P. Whelan, J. M. Dye, and K. Chandran. 2012. Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor. Viruses 4:2471-2484

Ng, M., E. Ndungo, R. K. Jangra, Y. Cai, E. Postnikova, S. R. Radoshitzky, J. M. Dye, E. Ramirez de Arellano, A. Negredo, G. Palacios, J. H. Kuhn, and K. Chandran. 2014. Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1. Virology 468-470:637-646

 

 

 

Silvana Opp, Diaz-Griffero Lab 

Fricke, T., C. Buffone, S. Opp, J. Valle-Casuso, and F. Diaz-Griffero. 2014. BI-2 destabilizes HIV-1 cores during infection and prevents binding of CPSF6 to the HIV-1 capsid. Retrovirology 11:120

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

 

 

 

Bianca Schulte, Diaz-Griffero Lab 

Fricke, T., T. E. White, B. Schulte, D. A. de Souza Aranha Vieira, A. Dharan, E. M. Campbell, A. Brandariz-Nunez, and F. Diaz-Griffero. 2014. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology 11:68

Schulte, B., C. Buffone, S. Opp, F. Di Nunzio, D. A. De Souza Aranha Vieira, A. Brandariz-Nunez, and F. Diaz-Griffero. 2015. Restriction of HIV-1 requires the N-terminal region of MxB as a capsid-binding motif but not as a nuclear localization signal. J Virol 89:8599-8610

Buffone, C., B. Schulte, S. Opp, and F. Diaz-Griffero. 2015. Contribution of MxB oligomerization to HIV-1 capsid binding and restriction. J Virol 89:3285-3294

Malikov, V., E. S. da Silva, V. Jovasevic, G. Bennett, D. A. de Souza Aranha Vieira, B. Schulte, F. Diaz-Griffero, D. Walsh, and M. H. Naghavi. 2015. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun 6:6660

 

 

 

Shalu Sharma, Porcelli Lab 

Arora, P., A. Baena, K. O. Yu, N. K. Saini, S. S. Kharkwal, M. F. Goldberg, S. Kunnath-Velayudhan, L. J. Carreno, M. M. Venkataswamy, J. Kim, E. Lazar-Molnar, G. Lauvau, Y. T. Chang, Z. Liu, R. Bittman, A. Al-Shamkhani, L. R. Cox, P. J. Jervis, N. Veerapen, G. S. Besra, and S. A. Porcelli. 2014. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-116

Carreno, L. J., S. S. Kharkwal, and S. A. Porcelli. 2014. Optimizing NKT cell ligands as vaccine adjuvants. Immunotherapy 6:309-320

Venkataswamy, M. M., T. W. Ng, S. S. Kharkwal, L. J. Carreno, A. J. Johnson, S. Kunnath-Velayudhan, Z. Liu, R. Bittman, P. J. Jervis, L. R. Cox, G. S. Besra, X. Wen, W. Yuan, M. Tsuji, X. Li, D. D. Ho, J. Chan, S. Lee, R. Frothingham, B. F. Haynes, M. W. Panas, G. O. Gillard, J. D. Sixsmith, B. Korioth-Schmitz, J. E. Schmitz, M. H. Larsen, W. R. Jacobs, Jr., and S. A. Porcelli. 2014. Improving Mycobacterium bovis Bacillus Calmette-Guerin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. PLoS One 9:e108383

Singh, M., W. Quispe-Tintaya, D. Chandra, A. Jahangir, M. M. Venkataswamy, T. W. Ng, S. Sharma-Kharkwal, L. J. Carreno, S. A. Porcelli, and C. Gravekamp. 2014. Direct incorporation of the NKT-cell activator alpha-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy. Br J Cancer 111:1945-1954

 

 

 

Arti Shinde, Frangogiannis Lab 

Gonzalez-Quesada, C., M. Cavalera, A. Biernacka, P. Kong, D. W. Lee, A. Saxena, O. Frunza, M. Dobaczewski, A. Shinde, and N. G. Frangogiannis. 2013. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 113:1331-1344

Shinde, A. V., and N. G. Frangogiannis. 2014. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 70:74-82

Biernacka, A., M. Cavalera, J. Wang, I. Russo, A. Shinde, P. Kong, C. Gonzalez-Quesada, V. Rai, M. Dobaczewski, D. W. Lee, X. F. Wang, and N. G. Frangogiannis. 2015. Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 8:788-798

Shinde, A. V., and N. G. Frangogiannis. 2015. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium. Circ Res 117:10-12

 

 

 

Natalie Silmon de Monerri, Kim Lab 

Nardelli, S. C., F. Y. Che, N. C. Silmon de Monerri, H. Xiao, E. Nieves, C. Madrid-Aliste, S. O. Angel, W. J. Sullivan, Jr., R. H. Angeletti, K. Kim, and L. M. Weiss. 2013. The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications. mBio 4:e00922-00913

Silmon de Monerri, N. C., and K. Kim. 2014. Pathogens hijack the epigenome: a new twist on host-pathogen interactions. Am J Pathol 184:897-911

 

 

 

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