Folates in Health and Disease
Einstein-Montefiore Department of Medicine Grand Rounds
Thursday, February 4, 2010
First Floor Lecture Hall, Forchheimer/Einstein
Cherkasky Auditorium, Moses/Montefiore
I. David Goldman, MD
Professor, Department of Medicine (Oncology)
Professor, Department of Molecular Pharmacology
Susan Resnick Fisher Professor of Brain Cancer Research
Director, Albert Einstein Cancer Center
Dr. I. David Goldman’s research has characterized the kinetics, thermodynamics, and molecular basis of transport mediated by facilitative carriers with a focus on folate transporters. These studies have been integrated into a cellular pharmacological approach to elucidate the mechanisms of action of antifolates and the role transport plays as a determinant of antifolate activities and resistance. He recently cloned a novel proton-coupled folate transporter - PCFT (Cell, 2006), and demonstrated that mutations in this gene are the molecular basis for the autosomal recessive disorder, hereditary folate malabsorption.
Before joining Einstein, Dr. Goldman was on the faculties in Medicine and Pharmacology at the University of North Carolina in Chapel Hill and then Virginia Commonwealth University in Richmond VA, where he was Vice Chairman of the Department of Medicine and then Chief of the Division of Hematology/Oncology and Director of the Massey Cancer Center.
Dr. Goldman received a BA from New York University, and his MD and residency training in internal medicine at the University of Chicago, which were followed by postdoctoral fellowships at the Biophysical Laboratory of the Harvard Medical School and the National Cancer Institute in Bethesda MD.
This grand rounds is hosted by the Division of Oncology.
The objectives of this lecture are to provide an update on the current understanding of:
The biological importance of folates and the consequences of folate deficiency and excess
Drugs that block folate utilization in cancer treatment and their clinical applications, mechanisms of action and resistance
The role that membrane transporters plays in folate-deficiency states and cancer treatment with antifolates
Albert Einstein College of Medicine designates this educational activity for a maximum of 1 credit towards the AMA Physician’s Recognition Award. Each physician should claim only those credits that he/she actually spent in the educational activity.