Areas of Research: fungal pathogenesis; host-pathogen biology; regenerative medicine; innovative therapeutics; medical education
STUDENT AFFAIRS: The goal of my work in Student Affairs is to provide dedicated and individualized support to Einstein Medical Students throughout their basic science and clinical studies.
FUNGAL PATHOGENESIS: Since the late 1970s, the rates of many important human fungal infections have significantly increased. This dramatic rise is associated with the growing numbers of immunocompromised individuals, particularly patients receiving chemo- or immuno-therapy, recovering from invasive surgery, or individuals with HIV/AIDS. Despite the increased prevalence of mycotic diseases, there remains an enormous gap in knowledge and our current therapeutic armamentarium all too often fails to eradicate these insidious pathogens. The major focus of my laboratory is on the pathogenesis of human pathogenic fungi, especially Histoplasma capsulatum, Candida parapsilosis, and Cryptococcus neoformans.
NANOPARTICLE AND siRNA THERAPEUTICS FOR WOUND HEALING: A scecond focus area of the laboratory is on innovative approaches to wound healing, especially leveraging the delivery of compounds via nanoparticles. In collaboration with the laboratory of Dr. David Sharp (Physiology & Biophysics), we are targeting microtuble severing enzymes as a mechanism for tightly regulating cell migration in order to enhance tissue regeneration. In collaboration with Dr. Adam Friedman (Medicine [Dermatology] and Physiology & Biophysics) and Dr. Joel Friedman (Medicine and Physiology & Biophysics) we are exploring diverse applications of a novel, simple and inexpensive nanoparticle platform for drug delivery. We are exploring the therapeutic potential of nitric oxide delivered in sustained release by the nanoparticles for the treatment of diverse infectious diseases, including bacterial and fungal diseases.
NOSANCHUK LABORATORY PUBLICATIONS: http://www.ncbi.nlm.nih.gov/pubmed/?term=nosanchuk+j
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