Bhavapriya Vaitheesvaran, Ph.D.
My research interests center around using mass spectroscopy methodology to characterize metabolic networks. I use metabolomic/lipidomic methodology to characterize fuel dyregulation, and to measure the tissue specific action of insulin in regulating metabolism. Profiling small molecules within metabolic pathways (such as glycolysis, the TCA cycle and the pentose phosphate pathway), in combination with stable isotope assessments of metabolic flux, are powerful tools for describing/characterizing metabolic networks. The mass spectrometric approach for flux measurement I have helped develop measures the flow of carbon, per unit time, through the pathways of glucose metabolism, and serves an in vivo measure of actual metabolic enzyme activity. Stable isotope methods are part of a broad background I have in the use mass spectrometric methods for the study of intermediary metabolism.
My plans for the future is to integrate metabolomic/lipidomic and stable isotope flux methodologies, for characterizing a broad range of diseases, including Type II Diabetes and obesity. The Stable Isotope and Metabolomics Facility I play a key role in characterizes metabolomic/lipidomic/flux “fingerprints” in cancer biology, and the biology of infectious disease organisms. I think the techniques I have developed for characterizing fuel dysfunctions seen in diabetes and obesity will be valuable for diagnosis, and for designing treatments, in combating cancer, and virulent pathogenic microorganisms. I look forward to designing new mass spectrometric methods, for use in diabetes and obesity, as well as for combating cancer.
- Peripheral effects of FAAH deficiency on fuel and energy homeostasis: Role of dysregulated lysine acetylation. Vaitheesvaran, B; Yang, L.; Hartil, K.; Glaser, S.T; Yazulla, S; Bruce, J. E; Kurland, I.J. ( PLoS ONE 7(3): e33717. doi:10.1371/journal.pone.0033717)
- Yang, L.; Vaitheesvaran, B. ; Hartil K. ; Leroith D. ; Robinson, A. J. , Hoopmann, M. R. ; Eng, J. K. ; Kurland, I.J. ; Bruce, J. E., “ Fasted/Fed Mouse Metabolic Acetylome” (J Proteome Res. 2011 Sep 2;10(9):4134-49. Epub 2011)
- MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity. Vaitheesvaran B, Leroith D, Kurland IJ. Diabetologia. 2010 Jun 25. [Epub ahead of print].
- Advantages of dynamic “closed loop” stable isotope flux phenotyping over static “open loop” clamps in detecting silent genetic and dietary phenotypes. Vaitheesvaran B, Chueh F, Xu J, Trujillo C, Saad, MF, Lee WNP, McGuinness OP and Kurland IJ. Metabolomics, 10 Jun;6(2):180-190. Epub 2009 Nov 12.
- The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Cell. 2010 Jan 22;140(2):280-93.
- Improved energy expenditure, glucose utilization and insulin sensitivity in VAMP8 null mice. Zong H, Wang C, Vaitheesvaran B, KurlandIJ, Hong W and Pessin JE. (Diabetes 2010).
- Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med. 2006 Sep;12(9):1048-55. Epub 2006 Aug 13.
- Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesvaran B, Lee WN, Saad MF, Sleeman MW, Teitell MA, Kurland IJ.Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse.Diabetes. 2006 Dec;55(12):3372-80.
- Manonmani G, Bhavapriya V, Kalpana S, Govindasamy S, Apparanantham T.Antioxidant activity of Cassia fistula (Linn.) flowers in alloxan induced diabetic rats. J Ethnopharmacol. 2005 Feb 10;97(1):39-42. Epub 2004 Dec 19.
- Ravindranath RM, Basilrose Sr RM, Ravindranath NH, Vaitheeswaran B. (2003). Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth. J Biol Chem. 2003 May 30;278(22):20293-302. Epub 2003 Mar 25.
- Bhavapriya V, Kalpana S, Govindasamy S, Apparanantham T. (2001). Biochemical studies on hypoglycemic effect of Aavirai kudineer: a herbal formulation in alloxan diabetic rats. Indian J Exp Biol, 39(9):925-8.
- Bhavapriya V, Govindasamy S. (2000). Biochemical studies on the hypoglycemic effect of Aegle marmelose in streptozotocin diabetic rats. Indian Drugs, 37(10):474.
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