Division of Endocrinology & Diabetes

Bhavapriya Vaitheesvaran, Ph.D.

Dr. Bhavapriya Vaitheesvaran

Instructor, Department of Medicine (Endocrinology)


Professional Interests

My research interests center around using mass spectroscopy methodology to characterize metabolic networks. I use metabolomic/lipidomic methodology to characterize fuel dyregulation, and to measure the tissue specific action of insulin in regulating metabolism. Profiling small molecules within metabolic pathways (such as glycolysis, the TCA cycle and the pentose phosphate pathway), in combination with stable isotope assessments of metabolic flux, are powerful tools for describing/characterizing metabolic networks. The mass spectrometric approach for flux measurement I have helped develop measures the flow of carbon, per unit time, through the pathways of glucose metabolism, and serves an in vivo measure of actual metabolic enzyme activity. Stable isotope methods are part of a broad background I have in the use mass spectrometric methods for the study of intermediary metabolism.

 My plans for the future is to integrate metabolomic/lipidomic and stable isotope flux methodologies, for characterizing a broad range of diseases, including Type II Diabetes and obesity. The Stable Isotope and Metabolomics Facility I play a key role in characterizes metabolomic/lipidomic/flux “fingerprints” in cancer biology, and the biology of infectious disease organisms. I think the techniques I have developed for characterizing fuel dysfunctions seen in diabetes and obesity will be valuable for diagnosis, and for designing treatments, in combating cancer, and virulent pathogenic microorganisms.  I look forward to designing new mass spectrometric methods, for use in diabetes and obesity, as well as for combating cancer.


Selected Publications

• Intestinal Microbiota Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury.OBroin P, Vaitheesvaran B et al, International Journal of Radiation Oncology*Biology*Physics, Nov 2014.

• The Warburg effect - a balance of flux analysis. Review Article, Vaitheesvaran B et al, Metabolomics, Dec 2014.

• Integrated Control Of Hepatic Lipogenesis Vs. Glucose Production Requires FoxO Transcription Factors. Haeusler R, Hartil K, Vaitheesvaran B , Arrieta-Cruz I , CookJ , Knight C, Kammoun H , Febbraio M , Gutierrez-Juarez R , Kurland I, Accili D. Nat Communications, [Paper #NCOMMS-14-07088B]

• Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer. Vaitheesvaran B, Hartil K, Navare A, Zheng, OBroin P, Golden A, Guha, Lee W, Kurland IJ, Bruce JE.Metabolomics. 2014 Oct 1;10(5):920-937.

• Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins.Miao J, Haas JT, Manthena P, Wang Y, Zhao E, Vaitheesvaran B, Kurland IJ, Biddinger SB.J Lipid Res. 2014 Apr;55(4):659-67. doi: 10.1194/jlr.M043711. Epub 2014 Feb 10.

• Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice.Yang Y, Tarabra E, Yang GS, Vaitheesvaran B, Palacios G, Kurland IJ, Pessin JE, Bastie CC.PLoS One. 2013 Nov 28;8(11):e81866. doi: 10.1371/journal.pone.0081866. eCollection 2013.

• SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012.

• Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, Sun Y, Yang ES, Liu LP, Vaitheesvaran B, Bridges L, Kurland IJ, Strich R, Ni JQ, Wang C, Ericsson J, Pessin JE, Ji JY, Yang F. J Clin Invest. 2012 Jul 2;122(7):2417-27. doi: 10.1172/JCI61462. Epub 2012 Jun 11.

• Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV Jr, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. Cell Metab. 2012 Jun 6;15(6):873-84. doi: 10.1016/j.cmet.2012.05.002.

• Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation. Vaitheesvaran B, Yang L, Hartil K, Glaser S, Yazulla S, Bruce JE, Kurland IJ. PLoS One. 2012;7(3):e33717. doi: 10.1371/journal.pone.0033717. Epub 2012 Mar 19.

• The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching. Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE. J Proteome Res. 2011 Sep 2;10(9):4134-49. doi: 10.1021/pr200313x. Epub 2011 Aug 16.

• Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice. Zong H, Wang CC, Vaitheesvaran B, Kurland IJ, Hong W, Pessin JE. Diabetes. 2011 Jan;60(1):30-8. doi: 10.2337/db10-0231. Epub 2010 Sep 28.

• MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity. Vaitheesvaran B, LeRoith D, Kurland IJ.
o Diabetologia. 2010 Oct;53(10):2224-32. doi: 10.1007/s00125-010-1827-4. Epub 2010 Jun 25.

• Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes. Vaitheesvaran B, Chueh FY, Xu J, Trujillo C, Saad MF, Lee WN, McGuinness OP, Kurland IJ. Metabolomics. 2010 Jun;6(2):180-190. Epub 2009 Nov 12.

• The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041.



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