Division of Cardiology

Einstein-Montefiore Interventional Cardiology Research

With 9 diverse yet fully integrated adult cardiac catheterization and electrophysiology laboratories between 2 campuses, faculty research investigators with unparalleled expertise, and over 5,000patients seen each year, the Einstein-Montefiore Interventional Cardiology Service conducts extensive research activity, including investigator-initiated studies, industry-sponsored clinical trials, and participation in national registries.

Over the past 20 years, research faculty and fellowship trainees have carried out over 25 research studies. Query: is this figure correct? It seems low given the number of current investigations. Einstein-Montefiore’s notable success in conducting groundbreaking interventional cardiology research studies is due to a number of factors, including:

  • widely diverse patient population
  • track record of success in recruiting women and minorities into research studies
  • investigations conducted according to the highest ethical and clinical standards
  • opportunities to collaborate with investigators in numerous subspecialties, including Einstein-Montefiore’s world-class epidemiology public health, and cardiovascular experts
  • access to General Clinical Research Centers (GCRCs) and core clinical research facilities at both Einstein and Montefiore

Thrombolysis in Myocardial Infarction (TIMI) Trial
Examination of factors related to thrombolysis in myocardial infarction (TIMI) during the treatment of unstable ischemic events.

Nitric Oxide for MI Treatment During Angioplasty
Nitric oxide may aid myocardial salvage if administered in a timely manner during myocardial infarction.

Periscope Trial
Multicenter study to compare Actos (pioglitazone HCl) and Amaryl (glimepiride) to determine whether either drug causes a change in coronary artery atheroma.

Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D)
Evaluation of treatments for Type 2 diabetic patients with angiographically proven coronary artery disease and stable angina or ischemia, comparing initial treatment with angioplasty or bypass surgery to initial treatment with a medical program.

Effectiveness of Glycoprotein IIb/IIIa Inhibitor Use During Primary Coronary Angioplasty
Examination of the pattern of GP IIb/IIIa use and its effectiveness in a large population-based cohort of patients who underwent primary angioplasty in New York State.

Percutaneous Coronary Interventions (PCI) Registry
Details of Einstein-Montefiore's participation in the nationwide PCI Registry.

Racial and Ethnic Factors in Response to Treatment
Einstein-Montefiore researchers are evaluating whether race- and ethnicity-based biological disparities in African American and Hispanic patients account for differences in response to pharmaceutical therapies. Einstein-Montefiore is one of 15 national centers participating in this NHLBI-sponsored study.

Vascular Imaging Technologies
Einstein-Montefiore investigators evaluated coronary artery imaging using optical coherence tomography (OCT). OCT uses infrared light delivered via a fiberoptic catheter to produce high-resolution, cross-sectional images of blood vessels (50 microns vs. the standard 200-300), OCT enables visualization of previously indetectable elements (e.g., macrophages).

Emergency Angioplasty
DETAIL NEEDED.

Treatment Devices
New and innovative treatment devices, including drug-eluting cobalt chromium stents coated with silurumus.

Pharmacological Treatment for MI
Einstein-Montefiore investigators are evaluating new pharmaceutical agents and drug combinations for post-myocardial infarction treatment, including anticoagulants and antiplatelet medications.

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