To facilitate the research programs of Einstein investigators by providing shared resources to study epigenetic modifications across the entire genome, including DNA methylation, histone modification and DNA-protein interactions.
This shared facility is part of Einstein’s Center for Epigenomics
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The Genomics Core serves the Einstein scientific community by providing a broad scala of services, utilizing current and emerging nucleic acid technologies. Microarrays, real-time PCR, Sanger sequencing and new, massively parallel sequencing (MPS; also known as next-gen sequencing) are available. The Core provides a number of technologies for genotyping DNA from humans or model organisms, varying from SNP (single nucleotide polymorphism) detecting to sequencing DNA for unknown variations. Furthermore, the Genomics Core performs quantitative CpG methylation analysis for the Epigenomics Core.
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Computational Genomics Core
The Computational Genomics Core (CGC) supports the Einstein community by providing essential informatics resources and infrastructure for the analysis and interpretation of large genomic and epigenomic datasets, providing for timely and standardized delivery of data to investigators, and to organize and present tutorials for data retrieval and analysis using the provided tools and methodologies. The CGC will develop primary analysis pipelines, analysis and visualization tools for application-specific handling of data using open-source and commercial analysis tools. All tools will be maintained and deployed in a manner that optimally supports the research activities of individual investigators.
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Molecular Cytogenetic Core
The Molecular Cytogenetic Core (MC) at the Albert Einstein College of Medicine provides tools for the preparation of human and murine samples suitable for molecular genetic and cytogenetic analysis of the entire genome. These tools include the establishment of EBV transformed cell lines; isolation of DNA and mRNA from a variety of tissue culture samples as well as primary biopsies; preparation of metaphase chromosomes suitable for fluorescence in situ hybridization (FISH) and Spectral Karyotyping (SKY) or whole chromosome paints for human and mouse genome. The core personnel is trained to hybridize commercial probes and to designed locus specific probes for regions of interest to investigators. All the probes are custom designed and in house generated.
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