Department of Genetics

Special Projects: The C. elegans Connectome Project

The Emmons Lab uses the model organism C. elegans to study nervous system wiring

The only complete wiring diagram of an animal nervous system available today is that of the hermaphrodite sex of the nematode worm Caenorhabditis elegans, determined over twenty years ago. The Emmons laboratory has now provided the second connectome, that of the posterior nervous system of the C. elegans male. They accomplished this feat after developing a software platform to speed analysis and annotation of electron micrographs of neural tissue. The C. elegans male posterior connectome consists of the processes of some 175 neurons connected by 5000 synapses, forming a neural network. This region of the male nervous system contains the circuits that govern male mating behavior, the most complex behavior of C. elegans. When compared to the hermaphrodite, the new connectivity data reveal for the first time extensive dimorphism between the nervous systems of the two sexes of a single species. Important questions now can be explored at the circuit level using the powerful genetic and molecular tools available in this model system. For example, how does a complex neural network form during development? How does the neural network function in a decision-making process that chooses and drives alternative behavioral outputs? Our wiring diagram now allows us to address these developmental and behavioral questions.

For more information, visit the Emmons Lab website 

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News & Events

News | Ozbudak Lab published a new paper in Development

Dr. Ertugrul Ozbudak and his laboratory have published a new paper in the journal, Development. read more

 

News | Jean Hebert paper published in Science

Einstein researchers led by Dr. Jean Hebert have found that inner-ear dysfunction can directly cause neurological changes that increase hyperactivity. read more

 

News | Highlighting the Functional Connectome

Dr. Scott Emmons has been selected as a presenter for the Neuroscience 2013 Presidential Special Lecture Series. read more

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