Research in the Department of Cell Biology is focused on understanding molecular mechanisms of gene regulation in eukaryotic cells. Using mammalian cells, yeast, viruses, fruit flies and transgenic mice, we are investigating mechanisms of DNA replication and repair, control of the cell cycle and apoptosis, roles for transcriptional regulation and chromatin structure in gene expression, RNA processing, intracellular trafficking, membrane fusion and budding, mechanisms of generating antibody diversity, and the functions of cell surface sugars.
The Frenette Lab published a new paper In Science
||New Science article from the Frenette Lab.
Claire Magnon,Simon J. Hall, Juan Lin, Xiaonan Xue, Leah Gerber, Stephen J. Freedland and Paul S. Frenette
Autonomic Nerve Development Contributes to Prostate Cancer Progression
Science 12 July 2013: Vol. 341 no. 6142, DOI: 10.1126/science.1236361
Congratulations to Drs Magnon and Frenette and the other authors on this outstanding accomplishment!
In the News
Dr. Ulrich Steidl has been promoted to Associate Professor of Cell Biology and of Medicine. Congratulations to Dr. Steidl on this very well deserved recognition of his outstanding scientific accomplishments and his many contributions to the Albert Einstein College of Medicine.
Sandra Pinho, a postdoctoral research fellow in the lab of Dr. Paul S. Frenette, was awarded with the 2013 New York Stem Cell Foundation (NYSCF) - Druckenmiller Research Fellowship and she will be presenting her work at the Eighth NYSCF Annual Translational Stem Cell Research Conference on October 16. Congratulations to Dr. Sandra Pinho and the lab of Dr. Paul Frenette.
New Paper from the Ye Lab - Huang, X., Meng, B., Iqbal, J., Ding, B.B., Perry, A.M., Cao, W., Smith, L.M., Bi, C., Jiang, C., Greiner, T.C., Weisenburger, D., Rimsza, L., Rosenwald, A., Ott, G., Delabie, J., Campo, E., Braziel, R., Gascoyne, R., Cook, J., Tubbs, R., Jaffe, E., Armitage, J., Vose, J., Staudt, L., McKeithan, T.W., Chan, W., Ye, B.H.*, Fu, K*. Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma patients treated with R-CHOP. (* Equal contribution authors) J Clin Oncol. 2013 Nov 12. [Epub ahead of print] PMID: 24220556.
New Paper from the Schildkraut Lab - Gerhardt J, Tomishima MJ, Zaninovic N, Colak D, Yan Z, Zhan Q, Rosenwaks Z, Jaffrey SR, and C.L. Schildkraut. The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Molecular Cell 53: November 27, 2014 [Epub ahead of print].
New Paper from the Stanley Lab - Miwa HE, Koba WR, Fine EJ, Giricz O, Kenny PA, Stanley P. Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. Glycobiology. Dec;23(12):1477-90. doi: 10.1093/glycob/cwt075. Epub 2013 Sep 13..
New Paper from the Edelmann and Scharff Lab - J M M van Oers, Y Edwards, R Chahwan, W Zhang, C Smith, X Pechuan, S Schaetzlein, B Jin, Y Wang, A Bergman, M D Scharff and W Edelmann. The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene advance online publication 9 September 2013; doi: 10.1038/onc.2013.365.
New Papers from the Kielian Lab - Yan Zheng and Margaret Kielian. Imaging of the Alphavirus Capsid Protein during Virus Replication. J Virol. 2013 Sep;87(17):9579-89. doi: 10.1128/JVI.01299-13. Epub 2013 Jun 19.
Onyinyechukwu Uchime, Whitney Fields, and Margaret Kielian. The Role of E3 in pH Protection during Alphavirus Assembly and Exit. J. Virol. September 2013 87:10255-10262; published ahead of print 17 July 2013 doi:10.1128/JVI.01507-13.
New Paper from the Kielian Lab - Claudia Sánchez-San Martín, Soumya Nanda, Yan Zheng, Whitney Fields and Margaret Kielian. Cross-inhibition of Chikungunya virus fusion and infection by alphavirus E1 domain III proteins. J Virol. 2013 Jul;87(13):7680-7. doi: 10.1128/JVI.00814-13. Epub 2013 May 1.
New Paper from the Stanley Lab - Müller R, Jenny A, Stanley P. The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila. PLoS One. 2013 May 9;8(5):e62835. doi: 10.1371/journal.pone.0062835. Print 2013.
New Paper from the Fyodorov Lab and the Skoultchi Lab - Lu, X., Wontakal S.N., Kavi H., Kim B.J, Guzzardo P.M., Emelyanov A.V., Xu N., Hannon G.J., Zavadil J. Fyodorov D.V. and Skoultchi A.I. (2013). Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9. Science 340(6128): 78-81. PMID: 23559249.
New Paper from the Steidl Lab - Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, Steidl U. Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nature Immunology (2013); Apr 7; doi:10.1038/ni.2572.
New Paper from the Query lab - Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query CC, Xu YZ. Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Res. 2013 Mar 5. [Epub ahead of print] doi:10.1093/nar/gkt149 PMID: 23462954.
New Paper from the Ye lab - Ding, B.B., Bi, E., Chen, H., Yu, J.J. and Ye, B.H. IL-21/STAT3 and CD40L/NF-KappaB synergistically promote plasma cell differentiation through upregulation of Blimp-1. J Immunol. 2013 Feb 15;190(4):1827-36. PMID: 23325890.
New Paper from the Skoultchi lab - Yang SM, Kim BJ, Norwood Toro L, Skoultchi AI. H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1708-13. PMID:23302691.
New Paper from the Kielian lab - Fields W, Kielian M. A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion. J Virol. 2013 Apr: 87(7):3774-81. doi:10.1128/JVT. 03310-12. Epub. 2013 Jan 16.
New Paper from the Schildkraut lab - Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung P, Schildkraut C, Pagano M. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. J Cell Biol. 2013 Jan 21;200(2):141-9. doi: 10.1083/jcb.201209002. Epub 2013 Jan 14. PMID: 23319600.
New Papers from the Steidl lab- Pandolfi A, Barreyro L, Steidl U. Pre-leukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Trans Med. 2013 Feb; 2:143-150
Will B, Zhou L, Vogler TO, Ben-Neriah S, Schinke C, Tamari R, Yu Y, Bhagat T, Bhattacharya S, Barreyro L, Heuck C, Mo Y, Parekh S, McMahon C, Pellagatti A, Boultwood J, Montagna C, Silverman L, Maciejewski J, Greally J, Ye BH, List A, Steidl C, Steidl U*, Verma A*. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations. Blood. 2012 Sep; 120:2076-2086.
Kawahara M*, Pandolfi A*, Bartholdy B*, Barreyro L, Will B, Roth M, Okoye UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-like homeobox (Hlx) regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell. 2012 Aug; 22:194-208.
* co-first authors.
Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, Ben-Neriah S, Montagna C, Parekh S, Pellagatti A, Boultwood J, Paietta E, Ketterling RP, Cripe L, Fernandez HF, Greenberg PL, Tallman MS, Steidl C, Mitsiades CS, Verma A, and Steidl U. Overexpression of interleukin 1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood. 2012 Aug; 120:1290-1298.