Research in the Department of Cell Biology is focused on understanding molecular mechanisms of gene regulation in eukaryotic cells. Using mammalian cells, yeast, viruses, fruit flies and transgenic mice, we are investigating mechanisms of DNA replication and repair, control of the cell cycle and apoptosis, roles for transcriptional regulation and chromatin structure in gene expression, RNA processing, intracellular trafficking, membrane fusion and budding, mechanisms of generating antibody diversity, and the functions of cell surface sugars.
In the News
||At its April 15th Convocation, the Albert Einstein College of Medicine honored two of our faculty members by investing them with endowed chairs: Dr. Winfried Edelmann as the Joseph and Gertrud Buchler Chair in Transgenic Medicine and Dr. Margaret Kielian as the Samuel H. Golding Chair in Microbiology.
Our warmest congratulations to Drs. Edelmann and Kielian on this very well deserved recognition of their scientific accomplishments and contributions to the Einstein community!
On April 12, 2013,Gloria Kung, of Dr. Kitsis' Lab successfully defended her thesis. Our warmest congratulations to Dr. Gloria Kung and the Kitsis laboratory.
On April 5, 2013,Wendy McKimpson, of Dr. Kitsis' Lab successfully defended her thesis. Our warmest congratulations to Dr. Wendy McKimpson and the Kitsis laboratory.
On March 22, 2013,Elena Tosti, of Dr. Edelmann's Lab successfully defended her thesis. Our warmest congratulations to Dr. Elena Tosti the Edelmann laboratory.
On March 8, 2013,Yan Zheng, of Dr. Kielian's Lab successfully defended her thesis. Our warmest congratulations to Dr. Yan Zheng and the Kielian laboratory.
Laura Barreyro, a graduate student in the lab of Dr. Ulrich Steidl, was awarded the 2013 Julius Marmur Research Award and she will be presenting her work at the 17th Annual Julius Marmur Symposium on March 18th. Congratulations to Laura and the Steidl lab!
Dr. Mathieu Dube, a Postdoctoral Fellow in the lab of Dr. Margaret Kielian, has awarded a postdoctoral fellowship from the ''Fond de la Recherche en Santé du Québec (FRSQ)''. Congratulations to Dr. Mathiew Dube and the lab of Dr. Margaret Kielian!
On February 21, 2013, Chanjung Chang of Dr. Eric Bouhassira's Lab successfully defended his thesis. Our warmest congratulations to Dr. Chanjung Chang and the Bouhassira laboratory.
Ashley Pandolfi - a Graduate Student in the lab of Dr. Ulrich Steidl, has received an NIH Ruth L. Kirschstein NRSA Fellowship. The department is very proud of Ashley on this achievement. Congratulations to Ashley Pandolfi and the lab of Dr. Ulrich Steidl!!.
New Paper from the Stanley Lab - Müller R, Jenny A, Stanley P. The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila. PLoS One. 2013 May 9;8(5):e62835. doi: 10.1371/journal.pone.0062835. Print 2013.
New Paper from the Fyodorov Lab and the Skoultchi Lab - Lu X, Wontakal SN, Kavi H, Kim BJ, Guzzardo PM, Emelyanov AV, Xu N, Hannon GJ, Zavadil J, Fyodorov DV, Skoultchi AI. Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9. PMID: 23559249.
New Paper from the Steidl Lab - Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, Steidl U. Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nature Immunology (2013); Apr 7; doi:10.1038/ni.2572.
New Paper from the Query lab - Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query CC, Xu YZ. Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Res. 2013 Mar 5. [Epub ahead of print] doi:10.1093/nar/gkt149 PMID: 23462954.
New Paper from the Ye lab - Ding, B.B., Bi, E., Chen, H., Yu, J.J. and Ye, B.H. IL-21/STAT3 and CD40L/NF-KappaB synergistically promote plasma cell differentiation through upregulation of Blimp-1. J Immunol. 2013 Feb 15;190(4):1827-36. PMID: 23325890.
New Paper from the Skoultchi lab - Yang SM, Kim BJ, Norwood Toro L, Skoultchi AI. H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1708-13. PMID:23302691.
New Paper from the Kielian lab - Fields W, Kielian M. A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion. J Virol. 2013 Apr: 87(7):3774-81. doi:10.1128/JVT. 03310-12. Epub. 2013 Jan 16.
New Paper from the Schildkraut lab - Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung P, Schildkraut C, Pagano M. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. J Cell Biol. 2013 Jan 21;200(2):141-9. doi: 10.1083/jcb.201209002. Epub 2013 Jan 14. PMID: 23319600.
New Papers from the Steidl lab- Pandolfi A, Barreyro L, Steidl U. Pre-leukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Trans Med. 2013 Feb; 2:143-150
Will B, Zhou L, Vogler TO, Ben-Neriah S, Schinke C, Tamari R, Yu Y, Bhagat T, Bhattacharya S, Barreyro L, Heuck C, Mo Y, Parekh S, McMahon C, Pellagatti A, Boultwood J, Montagna C, Silverman L, Maciejewski J, Greally J, Ye BH, List A, Steidl C, Steidl U*, Verma A*. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations. Blood. 2012 Sep; 120:2076-2086.
Kawahara M*, Pandolfi A*, Bartholdy B*, Barreyro L, Will B, Roth M, Okoye UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-like homeobox (Hlx) regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell. 2012 Aug; 22:194-208.
* co-first authors.
Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, Ben-Neriah S, Montagna C, Parekh S, Pellagatti A, Boultwood J, Paietta E, Ketterling RP, Cripe L, Fernandez HF, Greenberg PL, Tallman MS, Steidl C, Mitsiades CS, Verma A, and Steidl U. Overexpression of interleukin 1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood. 2012 Aug; 120:1290-1298.
Roth M, Will B, Simkin G, Rao S, Barreyro L, Bartholdy B, Tamari R, Mitsiades CS, Verma A, Steidl U. Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood. 2012 Jul; 120:386-94.
New Paper from the Schildkraut lab - Demczuk, A., M. G. Gauthier, I.Veras, S. Kosiyatrakul, C. L. Schildkraut, M. Busslinger, J.Bechhoefer and P. Norio. 2012. Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment. PLoS Biology, inpress.
New Paper from the Query lab - Konarska MM. Query CC. CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome. RNA. 2012 May;18(5):1001-13. Epub 2012 Mar 8.
New Paper from the Schildkraut lab - William C. Drosopoulos, Settapong T. Kosiyatrakul, Zi Yan, Simone G. Calderano, and Carl L. Schildkraut. Human telomeres replicate using chromosome-specific, rather than universal, replication programs. JCB April 16, 2012, vol. 197 no. 2 253-266
New Paper from the Stanley lab - Batista F, Lu L, Williams SA, Stanley P. Complex N-Glycans Are Essential, but Core 1 and 2 Mucin O-Glycans, O-Fucose Glycans, and NOTCH1 Are Dispensable, for Mammalian Spermatogenesis. Biol Reprod. 2012 Apr 4.
New Paper from the Query lab - Shao W, Kim HS, Cao Y, Xu YZ, Query CC. A U1-U2 snRNP interaction network during intron definition. Mol Cell Biol. 2012 Jan;32(2):470-8. Epub 2011 Nov 7.
New Paper from Two Recent Ph.D. Graduates of the Department of Cell Biology – In this paper, Drs. Sabrina Volpe and Sandeep Wontakal, two recent Ph.D. Graduates of the Department of Cell Biology, and Michelle Maxson a student in the Department of Microbiology and Immunology, describe the origins of and their experiences initiating the first student-run course at Einstein. This article also contains a very useful compilation of suggested “landmark” papers in numerous fields of biomedical science. From Bio 101 to Pillars of Biology: A Pedagogical Experiment. Michelle E. Maxson, MS, Sabrina A. Volpi, PhD,and Sandeep N. Wontakal, PhD Einstein Journal of Biology and Medicine. 2011; 27(2):86-93.
New Paper from the Skoultchi lab- Wontakal SN, Guo X, Smith C, Maccarthy T, Bresnick EH, Bergman A, Snyder MP, Weissman SM, Zheng D, Skoultchi AI. A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3832-7. Epub 2012 Feb 22.
New Paper from the Guo lab- Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA. Slug and sox9 cooperatively determine the mammary stem cell state. Cell. 2012 Mar 2;148(5):1015-28.
New Paper from the Kielian lab- Liu Y. C. and Kielian M. Identification of a Specific Region in the E1 Fusion Protein Involved in Zinc Inhibition of Semliki Forest Virus Fusion. J. Virol. April 2012 86:3588-3594
New Paper from the Birshtein lab- Volpi SA, Verma-Gaur J, Hassan R, Ju Z, Roa S, Chatterjee S, Werling U, Hou H Jr, Will B, Steidl U, Scharff M, Edelman W, Feeney AJ, Birshtein BK. Germline Deletion of Igh 3' Regulatory Region Elements hs 5, 6, 7 (hs5-7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus. J. Immunol. 2012 Feb 17.