Einstein-Rockefeller-CUNY Center for AIDS Research

New 2016 NIH Grants Awards

Tuberculosis (TB) is the leading cause of death worldwide among people infected with HIV. But as yet, no test can reliably show when latent (inactive) TB infections in people with HIV starts progressing to active—and potentially fatal—TB disease. Dr. Jacqueline Achkar, an ERC CFAR investigator has received a five-year, $3.7 million National Institutes of Health grant to identify biomarkers that signal an increase in activity by Mycobacterium tuberculosis (Mtb), the bacterium that causes TB, in people with HIV.

Dr. Kathy Anastos, Director of the ERC-CFAR Clinical Core and Dr. Denis Nash, Associate Director of the ERC-CFAR led a team from the Albert Einstein College of Medicine, Montefiore and the City University of New York (CUNY) who have received a $9.4 million grant from the National Institutes of Health (NIH) to lead research in Central Africa to improve clinical care and health outcomes for patients with HIV. The ongoing, five-country observational study, called Central Africa International Epidemiologic Databases to Evaluate AIDS (CA-IeDEA), involves more than 50,000 HIV-positive children and adults taking anti-retroviral therapy (ART).

Dr. Laurie Bauman, Director of the ERC-CFAR Behavioral Core, leads a group of researchers at Montefiore, Albert Einstein College of Medicine and Columbia University Medical Center who have been awarded nearly $3 million from the National Institute of Mental Health to increase the use of pre-exposure prophylaxis (PrEP)—a medication that reduces the risk of contracting HIV. The intervention will integrate PrEP into Montefiore primary care practices throughout the Bronx, a borough with one of the highest HIV rates in the nation.

Dr. Harris Goldstein, Director of the ERC-CFAR, is part of the BELIEVE (Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral Eradication) consortium led by Dr. Doug Nixon at the George Washington School of Medicine, one of six Martin Delaney Collaboratory programs funded by the National Institutes of Health to accelerate HIV/AIDS cure research. Dr. Goldstein’s $1.3 million portion of the grant will fund a project focused on treating and reprogramming natural killer cells to amplify their capacity to kill HIV-infected cells.

Drs. Ganjam Kalpana and Vinayaka Prasad have been awarded $3.14 million grant by the National Institute of Health over 5 years to study CNS HIV reservoirs and the effect of illicit drugs on these reservoirs. This research project will utilize on a novel ultra-sensitive assay developed by Dr. Kalpana in collaboration with Dr. Singer to detect the reactivation of latent HIV proviruses in individual brain cells such as microglia to develop and evaluate strategies to eradicate HIV reservoirs in the brain.

 
 

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ERC-CFAR at a Glance

Partner Institutions 

  • Albert Einstein College of Medicine
  • Rockefeller University
  • The City University of New York (CUNY)
 

Investigators 

Total ERC-CFAR members

  • 183 Full members
  • 10 Affiliate members

CFAR member trainees funded by NIH K awards

  • 15 Full members
 

NIH Funding 

FY2015 OAR NIH AIDS FRB grants

$34,084,840 Total costs

 

New NIH AIDS grants awarded in FY2016

$7,345,645 Total annual costs

 

FY2014 non-AIDS NIH grants

$34,745,334 Total costs

Publications (first 6 months of 2016) 

Total Publications: 240

Publications multi-authored
by ERC-CFAR members: 91

Cores 

Administrative 

Director: Dr. H. Goldstein

 

Developmental 

Directors: Dr. V. Prasad & Dr. C. Cunningham

 

Biomarkers & Advanced Technologies 

Directors: Dr. J. Berman & Dr. S. Almo

 

Behavioral Science 

Director: Dr. L. Bauman

 

Clinical Translational Implementation Science 

Director: Dr. K. Anastos

 

Scientific Working Groups 

HIV and Eradication 

Directors: Dr. G. Kalpana & Dr. M. Caskey

 

Patient and Population Health Outcomes Research 

Directors: Dr. D. Nash & Dr. J. Arnsten  

New 2016 NIH Grants Awards 

 
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In the Media

Vice interviews Harris Goldstein, M.D., about the difficulty of developing a vaccine for HIV. Dr. Goldstein is professor of pediatrics and of microbiology & immunology at Einstein and director of the Einstein-Rockefeller-CUNY Center for AIDS Research. (Wednesday, Aug 30, 2017)

Crain’s Health Pulse interviews Dr. Laurie Bauman regarding a collaborative study aimed at controlling the spread of HIV using PrEP, a drug proven to reduce risk. Dr. Bauman is a principal investigator on the study, which includes Einstein, Montefiore and Columbia. She also is director of the Preventive Intervention Research Center and professor of pediatrics. (Friday, Jul 29, 2016)

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