Einstein-Sinai Diabetes Research Center

Clinical Research Methodology Sub-Core


Leader: Jill P. Crandall, MD 

Co-leader: Meredith Hawkins, MD 

The Einstein Clinical Research Methodology (CRM) sub-core promotes high-quality diabetes translational research through consultation, training, and mentoring in clinical research methods applicable to diabetes.

The CRM sub-core provides resources for diabetes research by extending its faculty’s reach to other programs and projects as mandated by the P&C guidelines.

The CRM sub-core partners with the newly established Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore (ICTR) to support research programs in diabetes, obesity and metabolism.

Services

CRM services represent the broad expertise of its investigators and encompass studies in clinical physiology, diabetes and obesity clinical trials, and epidemiology.

  1. Assistance and consultation to investigators at multiple stages of research design and implementation:
    • consultation about study design and analysis
    • assistance with selection of appropriate metabolic variables, biomarkers and clinical outcome measures
    • assistance with recruitment and retention of study subjects
    • development and application of innovative diabetes clinical research methodologies
    • consultation about use of established data sets and databases for epidemiological research
     
  2. Training in research methods specific to diabetes-related research:
    • mentoring of trainees from multiple disciplines in diabetes-related clinical research projects
    • structured seminar/workshop program for diabetes clinical research trainees
     

CRM Faculty Leaders

  • Jill P. Crandall, MD, Associate Professor of Medicine, is Director of the Montefiore/Einstein Diabetes Clinical Trials Unit. Dr. Crandall supervises the clinical research training activities of the unit and consultation with established and new investigators in clinical research methodology.

  • Meredith Hawkins, MD, Professor of Medicine and co-leader of the CRM sub-core, brings substantial experience in the assessment of insulin sensitivity (euglycemic-hyperinsulinemic clamp studies), adipose tissue physiology and inflammation. Dr. Hawkins provides consultation in the application of these techniques and the selection of clinical and biological outcome variables.

  • Clyde B. Schechter, MA, MD, Associate Professor of Family Medicine and of Epidemiology & Population Health, brings substantial experience in research utilizing large public-access databases (NHANES, etc.), cost analyses, and simulation modeling.

CRM Resource Faculty Members

  • Harry Shamoon, MD , is Associate Dean for Clinical and Translational Research and Professor of Medicine (Endocrinology). His laboratory has studied the mechanisms and treatment for defective counterregulation of hypoglycemia in type 1 diabetes, and he has directed major clinical trials at Einstein such as the Diabetes Control and Complications Trial (DCCT) and the Diabetes Prevention Program (DPP).
  • Rubina Heptulla, MD, Professor of Pediatrics (Endocrinology), is the Division Chief of Pediatric Endocrinology. Dr. Heptulla’s research focuses on discovering novel ways for delivery of multiple hormones along with preservation of beta cells; and examining the barriers to achieving delivery of patient treatments, specifically concerning the risk factors for adherence to regimens.
  • Hillel W. Cohen, DrPH, MPH, Professor of Clinical Epidemiology & Population Health, provides expertise in biostatistics.
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