aim of the Clinical and Translational Investigation Core (CTIC) is to facilitate
the ability of CFAR investigators to initiate or expand HIV/AIDS research by providing
a clinical and translational research platform that creates synergy across a
wide range of disciplines. Two major Core services designed to meet
this aim are a powerful web-based
IRB compliant relational database that integrates clinical, laboratory and treatment
information from HIV inpatient and outpatient visit electronic medical records and
a CFAR biorepository of serial plasma, PBMCs and cervical-vaginal lavage fluid
samples obtained from individuals newly-diagnosed with HIV, co-infected with HIV/HCV
and elite controllers/long-term nonprogressors.
- To provide a clinical and translational
research relational database platform that enables basic, clinical, and
behavioral researchers to access and leverage our extensive range of clinical
and research cohorts for rigorous translational AIDS research.
- To provide a biorepository that supports
the research needs of CFAR investigators.
- To identify epidemiologic trends in HIV
disease outcomes in areas with high HIV prevalence by providing access to
unique prospective cohorts of HIV-infected subjects.
- To engage Bronx-based HIV community group
leaders in designing and implementing clinical research studies.
- To train early stage investigators in
AIDS clinical and translational research, including consultation on grant
- To make current and future clinical and
translational researchers aware of expertise, services, and training available
through the CTIC; and to educate local HIV clinical providers about current
evidence-based practice and new developments in HIV care.
web-based IRB-compliant relational
database that integrates clinical, laboratory and treatment information from the
electronic medical records of almost 3,000 HIV-infected individuals.
expanding biorepository of serial
plasma, PBMCs and cervical-vaginal lavage fluid samples obtained from
individuals either newly-diagnosed with HIV, co-infected with HIV/HCV and elite
broad-based CFAR Community Advisory Board consisting of leaders of a wide array
of Bronx-based HIV-related Community-based organizations that advises on how to
facilitate community-based research studies.
unified web-based clinical research
database that facilitates synergistic research activity by
combining data from diverse cohorts and specimen repositories into one
centralized relational database
to CFAR biorepositories linked to a clinical database that includes serial
samples from individuals newly infected with HIV, infected with HIV and HCV and
elite controllers as well as other biorepositories of vaginal swabs, CVL, plasma, and PBMCs
from over 300 women, including adolescents, HIV-infected and uninfected women,
pregnant women, and post-coital samples of whom a subset also provided cervical
or vaginal biopsies.
to data and samples from cohorts from Rwanda, Cameroon, Burundi and South Africa.
for the full-range of study design, initiation, implementation and evaluation
including IRB submission, processes for enabling patient recruitment,
enrollment and collection of historical information and data analysis and
- Practical issues associated with conducting
clinical and translational research
Clinical Practice (GCP),
Clinical Laboratory Practice (GCLP)
data safety and monitoring boards
a research team
- Training in new technologies and laboratory
techniques to enhance clinical and translational relevance.
- Coordination of AIDS Center CFAR Grand Rounds
Recent Core Publications
Dusingize JC, Hoover DR, Shi Q, Mutimura E, Kierfer E, Cohen
M, Anastos K. Association of serum albumin with markers
of nutritional status among HIV-infected and uninfected Rwandan women. PLoS One. 2012;7(4):e35079. PMCID:
Keller MJ, Malone AM, Carpenter CA, Lo Y, Huang M, Corey L,
Willis R, Nguyen C, Kennedy S, Gunawardana M, Guerrero D, Moss JA, Baum MM,
Smith TJ, Herold BC. Safety and pharmacokinetics of aciclovir
in women following release from a silicone elastomer vaginal ring. J Antimicrob Chemother. 2012. PubMed
Keller MJ, Madan RP, Torres NM, Fazzari MJ, Cho S, Kalyoussef
S, Shust G, Mesquita PM, Louissaint N, Chen J, Cohen HW, Diament EC, Lee AC,
Soto-Torres L, Hendrix CW, Herold BC. A randomized trial to assess anti-HIV
activity in female genital tract secretions and soluble mucosal immunity
following application of 1% tenofovir gel. PLoS
ONE. 2011;6(1):e16475. PMCID: PMC3026837.
Kierfer E, Hoover DR, Shi Q, Dusingize JC, Cohen M, Mutimura
E, Anastos K. Association of
pre-treatment nutritional status with change in CD4 count after antiretroviral
therapy at 6, 12, and 24 months in Rwandan women. PLoS One. 2011;6(12):e29625. PMCID: PMC3247268.
Kuniholm MH, Gao X, Xue X, Kovacs A, Anastos K, Marti D,
Greenblatt RM, Cohen MH, Minkoff H, Gange SJ, Fazzari M, Young MA, Strickler
HD, Carrington M. Human leukocyte antigen genotype and risk
of HIV disease progression before and after initiation of antiretroviral therapy.
Journal of Virology.
2011;85(20):10826-33. PubMed PMID: 21849458.
Berg KM, Litwin AH, Li
X, Heo M, Arnsten JH. Lack of sustained improvement in adherence or viral load
following a directly observed antiretroviral therapy intervention. Clinical
Infectious Diseases 2011;53:936-43.
Cunningham CO, Sohler NL, Cooperman NA, Berg KM, Litwin AH,
Arnsten JH. Strategies to improve access to and utilization of health care
services and adherence to antiretroviral therapy among HIV-infected drug users.
Subst Use Misuse. 2011;46:218-32. PMID: 21303242. Nahvi S, Litwin AH, Heo
M, Berg KM, Li X, Arnsten JH. Directly observed antiretroviral therapy
eliminates adverse effects of active drug use on adherence. Drug Alcohol
Depend. 2011. PubMed PMID: 21885212.
Polsky S, Floris-Moore M,
Schoenbaum EE, Klein RS, Arnsten JH, Howard AA. Incident hyperglycaemia among
older adults with or at-risk for HIV infection. Antivir Ther.
2011;16:181-8. PMID: 21447867.