The overarching aim of the Clinical and Translational Investigation Core (CTIC) is to facilitate
the ability of CFAR investigators to initiate or expand HIV/AIDS research by providing
a clinical and translational research platform that creates synergy across a
wide range of disciplines. Two major Core services designed to meet
this aim are the HIV Integrated Clinical Database (HICDB), a powerful web-based
IRB compliant relational database that integrates clinical, laboratory and treatment
information from HIV inpatient and outpatient visit electronic medical records and the HIV Integrated Research Database (HIRBD) which centralizes access to a CFAR biorepository of serial plasma, PBMCs and cervical-vaginal lavage fluid
samples obtained from individuals newly-diagnosed with HIV, co-infected with HIV/HCV
and elite controllers/long-term nonprogressors and additional repositories maintained by CFAR investigators such as the local WIHS repository.
- To provide a clinical and translational
research relational database platform that enables basic, clinical, and
behavioral researchers to access and leverage our extensive range of clinical
and research cohorts for rigorous translational AIDS research.
- To provide a biorepository that provides access to samples from the CFAR biorepository and those of CFAR investigators including to local WIHS biorepository that supports
the research needs of CFAR investigators.
- To identify epidemiologic trends in HIV
disease outcomes in areas with high HIV prevalence by providing access to
unique prospective cohorts of HIV-infected subjects and web-based access through the HICDB to clinical and laboratory data from almost 15,000 HIV-infected patients followed at Montefiore (see below Figure for an example of use of this database to correlate HIV viral load and CD4 count with ART).
- To engage Bronx-based HIV community group
leaders in designing and implementing clinical research studies.
- To train early stage investigators in
AIDS clinical and translational research, including consultation on grant
- To make current and future clinical and
translational researchers aware of the expertise, services, and training available
through the CTIC; and to educate local HIV clinical providers about current
evidence-based practice and new developments in HIV care.
web-based IRB-compliant relational
database HICDB that integrates clinical, laboratory and treatment information from the
electronic medical records of almost 15,000 HIV-infected individuals.
- A web-based relational database HIRDB, that provides access to a virtual repository and centralized data from HIV+ and HIV-negative participants in Einstein CFAR investigators' funded research.
expanding CFAR biorepository of serial
plasma, PBMCs and cervical-vaginal lavage fluid samples obtained from
individuals either newly-diagnosed with HIV, co-infected with HIV/HCV and elite
broad-based CFAR Community Advisory Board consisting of leaders of a wide array
of Bronx-based HIV-related Community-based organizations available to advise CFAR investigators on how to
facilitate community-based research studies.
- Consultation services for CFAR investigators supporting the planning, initiation and implementation of clinical and translational studies.
- Training on how to access and use the HIV Integrated Clinical Database (HICDB) provides access to the full array of clinical data for ~15,000 HIV+ and 217,000 HIV-negative patients. [For a demo of the database using screen captures, please click here. Username:dbmu\cfar and Password: CFAR and click the red boxes.]
- Training on how to use and apply for research studies the HIV Integrated Research Database (HIRDB) with Virtual Biorepository which centralizes data from HIV+ research participants (and HIV-negative controls) to provide CFAR members with access to a broad-based Biobank derived from “remainder” specimens, including tissue from individuals newly infected with HIV, infected with HIV and HCV and
elite controllers as well as other biorepositories of vaginal swabs, CVL, plasma, and PBMCs
from over 300 women, including adolescents, HIV-infected and uninfected women,
pregnant women, and post-coital samples of whom a subset also provided cervical
or vaginal biopsies.
to data and samples from Einstein CFAR investigator developed cohorts from Rwanda, Cameroon, Burundi and South Africa.
for the full-range of study design, initiation, implementation and evaluation
including IRB submission, linkage to Community leaders, processes for enabling patient recruitment,
enrollment and collection of historical information and data analysis and
Core Training Programs
- Utilization of the HICDB and HIRDB databases
- Practical issues associated with conducting
clinical and translational research
Clinical Practice (GCP),
Clinical Laboratory Practice (GCLP)
- Handling of
data safety and monitoring boards
- How to lead and manage a research team
- How to develop relationships with and work with collaborators including Community leaders and stakeholders.
- Training in new technologies and laboratory
techniques to enhance clinical and translational relevance.
- Coordination with the Developmental Core got selectionof AIDS Center CFAR Grand Rounds speakers.
Recent Core Publications
1. Batchelder AW, Brisbane M, Litwin AH, Nahvi S, Berg KM, Arnsten JH. "Damaging what wasn't damaged already": Psychological tension and antiretroviral adherence among HIV-infected methadone-maintained drug users. AIDS Care. 2013. Epub 2013/02/15. doi: 10.1080/09540121.2013.766303. PubMed Central PMCID: PMC3740002.
2. Brust JC, Berman AR, Zalta B, Haramati LB, Ning Y, Heo M, van der Merwe TL, Bamber S, Moll AP, Friedland GH, Shah NS, Gandhi NR. Chest Radiograph Findings and Time to Culture Conversion in Patients with Multidrug-Resistant Tuberculosis and HIV in Tugela Ferry, South Africa. PLoS ONE. 2013;8(9):e73975. Epub 2013/09/17. doi: 10.1371/journal.pone.0073975. PMCID: PMC3765317.
3. Cooperman NA, Shastri JS, Shastri A, Schoenbaum E. HIV Prevalence, Risk Behavior, Knowledge, and Beliefs Among Women Seeking Care at a Sexually Transmitted Infection Clinic in Mumbai, India. Health care for women international. 2013. Epub 2013/05/11. doi: 10.1080/07399332.2013.770004. PubMed PMID: 23659311.
4. Cunningham CO, Giovanniello A, Kunins HV, Roose RJ, Fox AD, Sohler NL. Buprenorphine treatment outcomes among opioid-dependent cocaine users and non-users. Am J Addict. 2013;22(4):352-7. Epub 2013/06/26. doi: 10.1111/j.1521-0391.2013.12032.x. PubMed PMID: 23795874; PubMed Central PMCID: PMC3694744
5. Cunningham CO, Roose RJ, Starrels JL, Giovanniello A, Sohler NL. Prior buprenorphine experience is associated with office-based buprenorphine treatment outcomes. J Addict Med. 2013;7(4):287-93. Epub 2013/06/01. doi: 10.1097/ADM.0b013e31829727b2. PubMed PMID: 23722632; PubMed Central PMCID: PMC3737355.
6. Fatahzadeh M, Schlecht NF, Chen Z, Bottalico D, McKinney S, Ostoloza J, Dunne A, Burk RD. Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection. Oral surgery, oral medicine, oral pathology and oral radiology. 2013;115(4):505-14. Epub 2013/02/05. doi: 10.1016/j.oooo.2012.11.004. PubMed PMID: 23375488.
7. Herold BC, Keller MJ, Shi Q, Hoover DR, Carpenter CA, Huber A, Parikh UM, Agnew KJ, Minkoff H, Colie C, Nowicki MJ, D'Souza G, Watts DH, Anastos K. Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women. J Acquir Immune Defic Syndr. 2013;63(4):485-93. Epub 2013/04/18. doi: 10.1097/QAI.0b013e3182961cfc. PubMed Central PMCID: PMC3706034.
8. Kuniholm MH, Anastos K, Kovacs A, Gao X, Marti D, Sette A, Greenblatt RM, Peters M, Cohen MH, Minkoff H, Gange SJ, Thio CL, Young MA, Xue X, Carrington M, Strickler HD. Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus. Genes and immunity. 2013;14(5):330-5. Epub 2013/05/03. doi: 10.1038/gene.2013.25. PubMed PMID: 23636221; PubMed Central PMCID: PMC3723800.
9. Kuniholm MH, Parrinello CM, Anastos K, Augenbraun M, Plankey M, Nowicki M, Peters M, Golub ET, Lurain N, Landay AL, Strickler HD, Kaplan RC. Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women. PLoS ONE. 2013;8(4):e61973. Epub 2013/04/25. doi: 10.1371/journal.pone.0061973. PubMed PMID: 23613990; PubMed Central PMCID: PMC3629158.
10. Megra B, Eugenin E, Roberts T, Morgello S, Berman JW. Protease Resistant Protein Cellular Isoform (PrP) as a Biomarker: Clues into the Pathogenesis of HAND. J Neuroimmune Pharmacol. 2013. Epub 2013/04/26. doi: 10.1007/s11481-013-9458-4. PubMed PMID: 23616272.
11. Shapiro ME, Mahoney JR, Peyser D, Zingman BS, Verghese J. Cognitive Reserve Protects Against Apathy in Individuals with Human Immunodeficiency Virus. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2013. Epub 2013/09/12. doi: 10.1093/arclin/act071. PubMed PMID: 24021844.