The Einstein-Montefiore Center for AIDS Research (CFAR) coordinates, stimulates and supports the multidisciplinary research activities of over 120 NIH-funded faculty investigators at the Albert Einstein College of Medicine (Einstein) and Montefiore Medical Center (Montefiore). Our CFAR plays a crucial role in enabling our investigators to uncover new mechanisms by which HIV-1 infects cells and causes disease and to translate these discoveries into new therapies, approaches and interventions to improve the treatment of HIV-1-infected individuals prevent the further spread of HIV-1 infection. This translational research is particularly relevant to members of our community which includes nearly 15,000 HIV-infected men and women infected with HIV-1, more than 90% Latino or African American as well as our affiliated international sites located in areas where HIV infection is endemic.
CFAR Educational, Mentoring and Research Support Activities
The Developmental Core
provides a wide array of structured programs to provide research mentoring to early stage investigators and investigators interested in expanding their research programs to HIV/AIDS-related research. All basic science, translational and clinical CFAR investigators can access these programs.
To initiate the mentoring process, please fill out the Einstein-Montefiore CFAR Individual Developmental Plan (click here
to download) and email Dr. Prasad
of Dr. Arnsten
The University of Wisconsin Institute for Clinical and Translational research hosts a website (click here
) that provides resources to improve research mentoring relationships. It provides curricula, assessment tools and resources relevant for mentors and mentees, as well as those who would like to implement mentor training.
RFA-HL-14-023: Clinical Research in the Prevention, Diagnosis, and Treatment of HIV-Related Heart, Lung, and Blood (HLB) Diseases in Adults and Children (R01). Application Due Dates: January 8, 2015.
RFA-HL-14-024: Basic Research in the Pathogenesis of HIV-Related Heart, Lung, and Blood (HLB) Diseases in Adults and Children (R01/R21). Application Due Dates: January 8, 2015.
PA-14-214: HIV Vaccine Vector-Host Interactions: Understanding the Biology and Immunology (R21):Application Due Dates: Standard AIDS and AIDS-related dates, January 7
PA-14-215: HIV Vaccine Vector-Host Interaction: Understanding the Biology and Immunology (R01):Standard AIDS and AIDS-related dates, May 7, September 7 & January 7
PA-14-216: B Cell Help Immunology Program for AIDS Vaccine Strategies (R01): Standard AIDS and AIDS-related date, May 7, September 7 & January 7
PA-14-217: NK Cells to Induced Immunological Memory to Prevent HIV Infection (R01):Standard AIDS and AIDS-related date, May 7, September 7 & January 7
PA-14-218: Fc Receptor (FCR) and Antibody Effector Function in HIV Vaccine Discovery (R01):Standard AIDS and AIDS-related date, May 7, September 7 & January 7
PA-13-377: Research on Malignancies in the Context of HIV/AIDS (R01/R21). Application Due Dates: January 8, 2015.
PAR -13-349: Sustained Release of Antivirals for Treatment or Prevention of HIV (SRATP) (R01). Application Due Dates: January 8, 2015; January 8, 2016.
PAR-13-267: Novel NeuroAIDS Therapeutics: Integrated Preclinical/Clinical Program (P01). Application Due Dates: January 8, 2015; January 8, 2016.
Please click here for further information.
The HIV Integrated Clinical Database (HICDB) provides access to the full array of clinical data for ~15,000 HIV+ and 217,000 HIV-negative patients. [For a demo of the database using screen captures, please click here. Username:dbmu\cfar and Password: cfar and click the red boxes.] For an example demonstrating how this database was used to obtain data for a study investigating the impact of population-based HIV treatment and adherence initiatives in the Bronx implemented in the past 6 years on control of HIV infection in the Bronx, please click here for a PowerPoint presentation of the data and analysis. The HIV Integrated Research Database (HIRDB) with Virtual Biorepository centralizes data from HIV+ research participants (and HIV-negative controls) and available specimens in the repositories maintained for Einstein CFAR investigators’ funded research. Please contact Dr. Kathy Anastos for login information to access the HICDB and HIRDB.
CFAR Web-based Clinical Research Informatics System
To facilitate clinical and translation research by CFAR investigators the Clinical and Translational Investigation Core (CTIC) has established unified web-based clinical research databases that combines data from diverse cohorts and specimen repositories into one centralized relational database.The HIV Integrated Research Database (HIRDB) with Virtual Biorepository centralizes data from HIV+ research participants (and HIV-negative controls) in Einstein to provide CFAR members with access to a broad-based Biobank derived from “remainder” specimens, including tissue. The HIV Integrated Clinical Database (HICDB) provides access to the full array of clinical data for ~15,000 HIV+ and 217,000 HIV-negative patients.
For a demo of the database using screen captures, please click here. Username:dbmu\cfar and Password: cfar and click the red boxes.
The CFAR HICDB and HIRDB are housed within the Einstein-Montefiore Centralized Informatics Commons, as conceptualized in the above Figure on the left, which centralizes and integrates data from all clinically and biologically relevant sources within their joint facilities. An example of results of an HICDB query to identify HIV-infected patients > 60 years of age by gender and demographic distributions is shown in the above Figure (on the right). For information about accessing the Databases and a demo of a query focused on correlating medications with viral load, please click here to link to the Clinical and Translational Core.