Albert Einstein Cancer Center

Selected Achievements: Cancer Epidemiology

The Burk laboratory reported very strong associations between CpG methylation in the HPV16 genome and cervical precancer/cancer, with potential implications for screening and for understanding viral oncogenicity (J Natl Cancer Inst 104:556-65, 2012. PMID: 22847263)

Strickler and colleagues found that HIV+ women with normal cervical cytology who test negative for oncogenic HPV have low 5-year risk of precancer/cancer, suggesting that less frequent screening of these women may be safe, similar to guidelines in HIV(-) women (JAMA 308:362-9, 2012. PMID: 22820789)

Anastos and collaborators working in Rwanda observed a significant association between cervical precancer/cancer and malaria among HIV+ women, consistent with hypotheses that malaria may have immunosuppressive effects independent of CD4+ count (PLoS One 5:e13525, 2010. PMID: 20976000) 

Rohan and colleagues reported that use of oral estrogen hormone therapy by postmenopausal women was associated with a greater than two-fold risk of proliferative breast disease, a condition associated with increased breast cancer risk (J Natl Cancer Inst 100:563-71, 2008. PMID: 18398105)

Gunter/Strickler and collaborators observed a positive association of serum insulin levels and risk of incident postmenopausal breast cancer and, further, that hyperinsulinemia better explained the obesity – breast cancer relationship than estrogen levels (J Natl Cancer Inst.103:826-34, 2011. PMID: 21447807)

Ho and her collaborators found that the relation between inflammatory cytokines and incident colorectal risk was made null by adjustment for insulin and leptin, and overall that high insulin/leptin levels may help explain the obesity – colorectal cancer relationship (Cancer Res 72:3029-37, 2012. PMID: 22511581)

Prezant and colleagues observed an excess of cancer cases in firefighters seven years post their exposure at the World Trade Center (Lancet 378:898-905, 2011. PMID: 21890054)

Agalliu and his collaborators reported strong positive associations between BRCA1/2 (DNA repair) mutations with high grade prostate cancer in a population of Ashkenazi Jews (Clin Cancer Res. 15:1112-20, 2009. PMID:19188187) 

 

 

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