Albert Einstein Cancer Center

Selected Achievements: Tumor Microenvironment & Metastasis

The Pollard laboratory showed that inhibition of CCL2-CCR2 signaling blocked recruitment of a distinct population of inflammatory monocytes that facilitate breast tumor metastases and prolonged survival of tumor-bearing mice. (Nature. 475:222-5, 2011. PMID 21654748; PLoS One. 4:e6562, 2009. PMID 19668346). 


Condeelis and his collaborators described the tumor microenvironment of metastasis (TMEM) as the tripartite arrangement of an invasive carcinoma cell, a macrophage, and an endothelial cell in primary breast tumor specimens that predicts for the development of systemic, hematogenous metastases independent of other prognostic indicators and lymph node status. (Clin Cancer Res. 15:2433-41, 2009. PMID 19318480) 


Condeelis and collaborators reported that theMena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. (J Cell Sci.124:2120-31, 2011. PMID 21670178) 


The Verkhusha laboratory developed: (i) monomeric fluorescent timers that toggle from blue to red in reporting on cellular trafficking (Nat Chem Biol. 2009 5:118-26, 2009.PMID:19136976), (ii) a two-laser multiphoton microscope was built for multichannel intravital fluorescence imaging that extends the wavelength range of excitation light, expands the number of simultaneously usable fluorophores, and markedly increases signal to noise (Nat Protoc. 6:1500-20, 2011. PMID 21959234) and (iii)a photoconvertible fluorescent reporter to track chaperone-mediated autophagy. (Nat Commum 2:386, 2011. PMID 21750540)  


Segall and his collaborators showed that stimulation of the early metastatic steps of motility and invasion by ErbB3 requires activation of the PI3-kinase pathway by the ErbB3 receptor as assessed by multiphoton microscopy. (Oncogene. 31:706-15, 2012. PMID: 21725367) 


The Kitsis laboratory established that the apoptosis inhibitor ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells. (Cancer Research 71:7705-15, 2011. PMID    22037876) 


The Di Cristofano laboratory reported that the increased incidence of invasive thyroid cancer by the activation of  phosphoinositide 3-kinase in Pten−/− female versus male mice, that he developed, is related to circulating estrogens and is modulated by p27.(Oncogene. 29:5678, 2010. PMID: 20676139) 


Hazan showed that p21CIP1 mediates reciprocal switching between proliferation and invasion during breast cancer metastasis. (Oncogene. 2012 Jul 2. [Epub ahead of print]. PMID: 22751124) 



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