Core Director: Jan Vijg, PhD
The Genomics and Epigenomics of Aging Core provides support for research efforts to unravel the molecular regulatory networks that control physiological homeostasis and longevity in organisms from yeast to humans.
The GEAC offers global genome and epigenome screening resources, including analysis pipelines, uniquely tailored to aging research.
- Advanced genomics of aging: design, implementation and data analysis. We will consult with investigators about experimental design, process flow and data analysis of genomics, epigenomics and transcriptomics experiments in aging and longevity studies. Institutionally supported sequencing and data analysis services are available to all and are at a discount for our members.
- Special applications of high-throughput genomics. We will provide experimental assistance to investigators working with very small amounts of material, down to single cells. For this purpose, the Vijg lab has developed single-cell genomics, single-cell transcriptomics and single-cell methylomics assays.
- Genotyping and in silico testing of candidate genes. We will provide web-based access to whole genome association and whole genome sequencing data from human centenarians and controls for in silico testing of candidate genes for association with longevity.
- Web-based access to whole genome association data from human centenarians and controls for in silico testing of candidate genes for association with longevity
- Sequence enrichment for next-generation re-sequencing of candidate gene regions
- Genome-wide DNA methylation analysis using the advanced HpaII tiny fragment Enrichment by Ligation-mediated PCR (HELP) platform
- Computational analysis of next-gen sequencing data
- Data repositories of genomic and epigenomic variants associated with aging and longevity
Services and Rates for the Genomics and Epigenomics of Aging Core (PDF)
For information regarding consultation fees, experimental design and methods, please contact email@example.com.