Institutional Animal Care and Use Committee

Policy No.0401: Production of Transgenic and Genetically Modified Mice

Approved by Animal Institute Committee: 11/24/04

Reapproved 6/15/2011

The Transgenic and Gene Targeting Facility (Transgenic Core) at Albert Einstein College of Medicine (AECOM) provides service to research Investigators for the generation of transgenic mice using the Transgenic Core’s animal use protocol approved by the Animal Institute Committee (AIC). However, Investigators planning to create transgenic mice at AECOM must have their own approved animal use protocol on file with the AIC for the production of transgenic mice. Detailed descriptions of procedures involved in the production of transgenic and knockout founder mice are not required if these procedures will be performed by the Transgenic Core following the Transgenic Core’s standard protocol. Investigators should provide their approved animal use protocol to the Transgenic Core at the time of request for the production of transgenic mice.

If transgenic or targeted mutant mice are created under the Transgenic Core’s animal use protocol before an Investigator has approval on his/her own animal use protocol, the mice will remain the responsibility of the Transgenic Core. Animals produced by the Transgenic Core cannot be transferred to the Investigator unless the Investigator has an approved animal use protocol. Animals that cannot be transferred to the Investigator due to the unavailability of an approved animal use protocol will have to be housed under the Transgenic Core’s animal use protocol until the Investigator’s approved animal use protocol is available.

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