Tuberculosis Research at Einstein

TB research home

 Mycobacterium tuberculosis, the agent causing tuberculosis, poses a formidable challenge to biomedical researchers as a consequence of its ability to evade the immune system, development of drug resistance and the failure of vaccines such as BCG to adequately induce long-term protective immunity.

Today, approximately a century after the discovery of the causative agent of tuberculosis by Robert Koch, it is estimated that as much as one-third of the entire human population on the planet is infected with Mycobacterium tuberculosis. Although most of these infected individuals harbor latent disease which is clinically silent, the global reservoir of active tuberculosis remains enormous with approximately 8 million new cases of active disease and two-to-three million deaths attributable to this infection each year.

To succeed in the fight against the global tuberculosis pandemic, it is clear that a multidisciplinary collaboration bringing together all of the resources of modern research and medicine.  At the Albert Einstein College of Medicine there are a number of clinicians and labs focused on TB research.  The EINSTEIN TB Research investigators basic and applied research in a wide variety of areas including understanding the mechanisms of pathogenesis and immune defense, drug development, the design of safer and more effective vaccines, development of diagnostics, drug resistance including MDR- and XDR-TB, and TB/HIV co-infection.

TB Researchers at EINSTEIN include the following:
 

Jacqueline M. Achkar, MD MS,  Assistant Professor, Department of Medicine (Infectious Diseases)

John S. Blanchard, PhD,  Professor, Department of Biochemistry; Dan Danciger Professor of Biochemistry

Arturo Casadevall, MD PhD, Chair, Department of Microbiology and Immunology; Professor, Department of Medicine (Infectious Diseases); Leo and Julia Forchheimer Chair in Microbiology and Immunology

John Chan, MD, Professor, Department of Medicine (Infectious Diseases); Professor, Department of Microbiology and Immunology

Glenn J. Fennelly, MD, Associate Professor of Clinical Pediatrics, Department of Pediatrics

Neel R. Gandhi, MD, Assistant Professor, Department of Medicine (General Internal Medicine); Assistant Professor, Department of Epidemiology and Population Health

William R. Jacobs, Jr., PhD, Professor, Department of Microbiology and Immunology; Professor, Department of Genetics; Investigator, Howard Hughes Medical Institute

Michelle H. Larsen, PhD, Assistant Professor, Department of Medicine (General Internal Medicine); Instructor, Department of Microbiology and Immnunology

Steven A. Porcelli, MD, Professor, Department of Microbiology and Immunology; Professor, Department of Medicine (Rheumatology); Murray and Evelyne Weinstock Chair in Microbiology and Immunology

Sarita Shah, MD, Assistant Professor, Department of Medicine (General Internal Medicine); Assistant Professor, Department of Epidemiology and Population Health

Drs. Jacobs, Porcelli, and Chan collaborate on an NIH-funded P01 Program Project Grant .

 


 


 


 
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