The Animal Physiology Core measures whole body and tissue-specific glucose sensitivity and insulin action using rodent models and analysis of whole body carbohydrate/fatty acid oxidation, energy expenditure, feeding behavior and locomotor activity using specialized metabolic and behavioral rodent cages. It performs specialized measurements of rodent adipose tissue distribution, metabolytes, and brain energy and glucose utilization. The facility staff provide instruction for investigators in designing and performing metabolic studies.
- In vivo assessment of energy balance, exercise, glucose/fatty acid metabolism, insulin secretion, insulin sensitivity and action by clamp technology
- Measurement of body fat composition/distribution, central nervous system energy and glucose utilization using a variety of noninvasive imaging modalities, including microCT and NMR
- Assessment of cardiac physiology in various experimental and therapeutic intervention models of diabetes and obesity
- Application of MRI and fMRI for metabolic analysis using the Einstein Gruss Magnetic Resonance Research Center (MRRC) and microPET through the Einstein MicroPET facility