Professor, Department of Anatomy & Structural Biology
Professor, Department of Cell Biology
Co-Chair, Department of Anatomy & Structural Biology
Harold and Muriel Block Chair in Anatomy & Structural Biology
Co-Director, Integrated Imaging Program
Co-Director, Gruss-Lipper Biophotonics Center
Studying Single mRNA Molecules from Cradle to Grave
We seek to understand the expression and movement of mRNA from transcription through degradation and the effect that defects in these processes have on health. We develop methods to label RNA in fixed and living cells using fluorescent probes and develop microscopy techniques and image analysis algorithms to visualize and quantify many mRNAs simultaneously. Using these technologies, we can observe single mRNAs localizing to cytoplasmic compartments such as the leading edge of a fibroblast, the bud tip of yeast or the axonal process of neurons and follow these single mRNAs from transcription, nuclear export through translation and degradation. Because these techniques yield quantitative fluorescence data, we are able to apply mathematical modeling to test mechanistic hypotheses.
More Information About Dr. Robert Singer
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 601
Bronx, NY 10461
Science interviews Dr. Robert Singer, who is identified as a pioneer in the field of mRNA research, about the ongoing search to discover how proteins are placed in their correct destinations within a cell.
Nature interviews Robert Singer, Ph.D., about recent advances in single-cell imaging and the enormous benefits a core facility with this technology provides to an institution’s investigators, students and postdocs.