Assistant Professor, Department of Obstetrics & Gynecology and Women's Health
Assistant Professor, Department of Genetics
Areas of Focus: Miscarriage, recurrent pregnancy loss, infertility.
Zev Williams MD PhD, is the Director of the Program for Early and Recurrent Pregnancy Loss (PEARL). He is Board Certified in Obstetrics and Gynecology as well as in Reproductive Endocrinology and Infertility. Dr. Williams completed his residency in Obstetrics and Gynecology at the Brigham and Women's Hospital/Massachusetts General Hospital at Harvard Medical School and his fellowship in Reproductive Endocrinology and Infertility at Weill-Cornell. His clinical and research focus is infertility with a special emphasis in helping those suffering from recurrent miscarriages.
Miscarriage is the most common complication of pregnancy affecting 1 in 5 pregnancies. However, in most cases the cause is not known. Our research program is focused on discovering causes of miscarriage and developing novel therapies to prevent miscarriage.
We recently comprehensively and quantitatively profiled microRNAs in circulation and were able to demonstrate tissue-specificity in origin of the microRNAs. Using the placenta as a model, we were further able to show that the microRNA fingerprint was sufficient to match the microRNA signature in a particular serum sample with the placenta from which the microRNAs were derived. As part of the NIH extracellular RNA (exRNA) consortium (http://exrna.org) we are now expanding this research to fully profile exRNAs and utlizing them for non-invasive monitoring of disease.
Prosdocimo, D., Anand, P., Liao, X., Zhu, H., Shelkay, S., Artero-Calderon, P., Zhang, L., Kirsh, J., Moore, D., Rosca, M.G., Vazquez, E., Kerner, J., Akat, K.M., Williams, Z., Zhao, J., Fujioka, H., Tuschl, T., Bai, X., Schulze, P.C., Hoppel, C.L., Jain, M.K., Haldar, S.M. KLF15 is a Critical Regulator of Cardiac Lipid Metabolism. (2014) JBC. In press.
Kudesia R, Li M, Smith J, Patel A, Williams Z. Rescue karyotyping: a case series of array-based comparative genomic hybridization evaluation of archival conceptual tissue. (2014) Reprod Biol Endocrinol. 12:19-27.
Williams, Z., Ben-Dov, I.Z., Elias, R., Mihailovic, A., Brown, M., Rosenwaks, Z., Tuschl., T. (2013). Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Natl Acad Sci U S A. 110:4255-60.
Williams, Z. (2012) Inducing tolerance to pregnancy. N Engl J Med. 367:1159-61.
Ascano, M., Mukherjee, N., Bandaru, P., Miller, JB., Nusbaum, J., Corcoran, J., Langlois, C., Munschauer, M., Hafner, M., Williams, Z., Ohler, U., and Tuschl, T. (2012) FMR1 targets distinct mRNA sequence elements to regulate protein expression. Nature. 492: 382-6.
Williams Z., Banks E., Bkassiny M., Jayaweera S.K., Elias R., Veeck L., Rosenwaks Z. (2012) Reducing multiples: a mathematical formula that accurately predicts rates of singletons, twins, and higher-order multiples in women undergoing in vitro fertilization. Fertil Steril. 98:1474-80.
More Information About Dr. S. Zev Williams
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Montefiore Medical Park
1695 Eastchester Road , Room 302
Bronx, NY 10461
The New York Times interviews Dr. Zev Williams about a study that investigated the use of progesterone therapy to prevent miscarriage.
The Wall Street Journal interviews Dr. Zev Williams about his research into new methods to monitor the health of the placenta during pregnancy.