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Faculty Profile

Bin Zhou, M.D., Ph.D.

Dr. Bin Zhou

Professor, Department of Genetics

Professor, Department of Pediatrics

Professor, Department of Medicine (Cardiology)

 

Professional Interests

The research of my lab focuses on molecular and cellular mechanisms in cardiovascular development and diseases. We apply an integrated approach of mouse genetics, developmental embryology, cell and molecular biology to study how cardiovascular precursor cells are specified and differentiated into different cardiovascular tissues during development and regeneration. We are currently working on four projects: (1) endocardial cell specification and differentiation, (2) transcriptional regulation of cardiac valve development, (3) modeling of heart valve diseases, and (4) epigenetic and genetic regulation of heart and coronary vessel development.

 

Selected Publications

  1. Zhou, B.*, Wu, B., Tompkins, K.L., Boyer, K.L., Grindley, J.C., and Baldwin, H.S. Characterization of NFATc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 132:1137-1146. 2005. PMID: 15689382 *Corresponding author
  2.  Chen J-W., Zhou, B.*, Shin, J., Schneider, M.D. H., BaldwinH.S., and Bergelson, J.M. Cardiomyocyte-Specific expression of the coxsackievirus and adenovirus receptor is essential for normal left ventricular development. Circ Res. 98:923-30. 2006. PMID: 16543498 *Co-first author
  3. Wu, H., Kao, S-C., Barrientos, T., Baldwin, H.S., Olson, E.N., Crabtree, G.R., Zhou, B. and Chang, C-P. DSCR1 is a transcriptional target of NFATc1 within the endocardium during heart development. J. Biol. Chem. 282:30673-9, 2007. PMCID: 2366997
  4. Langworthy, M., Zhou, B., de Caestecker, M., Moeckel G., and Baldwin, H.S. NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors J. Am. Soc. Nephrol. 20:311-21. 2009. PMCID: 2637056
  5. Ying, L., Lau, A, Alvira, C.M., West R., Cann G.M., Zhou, B., Kinnear, C., Jan, E., Sarnow, P., Van de Rijn, M., and Rabinovitch, M. LC3 Mediated Fibronectin mRNA Translation Induces Fibrosarcoma Growthby Increasing Connective Tissue Growth Factor. J. Cell Sci. 122:1441-5, 2009. PMCID: 2672968
  6. Zhou, B., Ma, Q., Kong, S.W., Hu, Y., Campbell, P.H., McGowan, F.X., Ackerman, K.G., Wu, B., Zhou, B., Tevosian S.G., and Pu, W.T. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J. Clin. Invest. 119(6):1462-76, 2009. PMCID: 2689123
  7. ZeiniM., HangC-T, Lehrer-Graiwer, J., Zhou, B., and Chang C-P. Endothelial calcineurin-NFAT signaling functions within a narrow developmental window to regulate coronary vascular patterning. Development136:3335-45,2009
  8. Wu, B., Zhou, B., Wang, Y., Cheng H-L, Hang, C.T., Pu, W.T., Chang, C-P and Zhou, B. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis 48:63-72, 2010. PMID: 20014345
  9. Hang, C.T., Yang, J., Han, P., Cheng, H.L., Shang, C., Ashley, E., Zhou, B., Chang, C-P. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466:62-7, 2010. PMCID: 2898892
  10. Wu, B., Wang, Y., Lui, W., Langworthy, M., Tompkins, K.L., Hatzopoulos, A.K., Baldwin, H.S., Zhou, B. Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation. Circ. Res. 109:183-192, 2011 NIHMSID: 299095. PMID: 21591072
  11. Wu, B., Zhang, Z.,Lui, W., Chen, X., Moreno-Rodriquez, R.A.,Wang, Y.,Chamberlain, A., Markwald, R.A., O’Rourke B., Sharp, D. J., Lenz, J., Baldwin, H.S.,Chang, C.P. and Zhou, B. Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial to Endocardial VEGF Signaling. Cell. 151(5):1083-1096, 2012
  12. Wang, Y, Wu, B, Chamberlain, AA, Lui, W, Koirala, P, Susztak, K, Klein, D, Taylor, V, Zhou, B. Endocardial to myocardial Notch-Wnt-Bmp axis regulates early heart valve development. PLoS ONE 8(4):e60244, 2013
  13. Xiong, Y, Li, W, Shang, C, Chen, R, Wu, B, Pan, P, Zhou, B, Longaker, M, Chang, C-P. Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair. Dev. Cell 25:169-181, 2013  

 

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 420
Bronx, NY 10461

Tel: 718.678.1067
Fax: 718.678.1016
bin.zhou@einstein.yu.edu

 
Pubmed Search
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